RNA m6A methylation in cancer

被引：30

作者：

Wang, Zhaotong ^{[1
]}

Zhou, Jiawang ^{[1
]}

Zhang, Haisheng ^{[1
]}

Ge, Lichen ^{[1
]}

Li, Jiexin ^{[1
]}

Wang, Hongsheng ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

来源：

MOLECULAR ONCOLOGY | 2023年 / 17卷 / 02期

基金：

中国国家自然科学基金;

关键词：

cancers; m(6)A; m(6)A modulators; mRNA; ncRNA; therapy; MESSENGER-RNA; RIBOSOMAL-RNA; BREAST-CANCER; READER YTHDC1; HEPATOCELLULAR-CARCINOMA; CELL-PROLIFERATION; XENOPUS-LAEVIS; NONCODING RNA; UP-REGULATION; NUCLEAR-RNA;

D O I：

10.1002/1878-0261.13326

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

N-6-methyladenosine (m(6)A) is one of the most abundant internal modifications in eukaryotic messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs). It is a reversible and dynamic RNA modification that has been observed in both internal coding segments and untranslated regions. Studies indicate that m(6)A modifications play important roles in translation, RNA splicing, export, degradation and ncRNA processing control. In this review, we focus on the profiles and biological functions of RNA m(6)A methylation on both mRNAs and ncRNAs. The dynamic modification of m(6)A and its potential roles in cancer development are discussed. Moreover, we discuss the possibility of m(6)A modifications serving as potential biomarkers for cancer diagnosis and targets for therapy.

引用

页码：195 / 229

页数：35

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