(Re)Appraising Remission in Ulcerative Colitis

被引：2

作者：

Sood, Ajit ^{[1
]}

Singh, Arshdeep ^{[1
]}

Mahajan, Ramit ^{[1
]}

Midha, Vandana ^{[2
]}

Bernstein, Charles N. ^{[3
]}

Rubin, David T. ^{[4
]}

机构：

[1] Dayanand Med Coll & Hosp, Dept Gastroenterol, Ludhiana, Punjab, India

[2] Dayanand Med Coll & Hosp, Dept Internal Med, Ludhiana, Punjab, India

[3] Univ Manitoba, Rady Fac Hlth Sci, IBD Clin & Res Ctr & Sect Gastroenterol, Max Rady Coll Med,Dept Med, Winnipeg, MB, Canada

[4] Univ Chicago Med, Ctr Inflammatory Bowel Dis, Chicago, IL USA

来源：

INFLAMMATORY BOWEL DISEASES | 2023年 / 29卷 / 08期

关键词：

Clinical remission; endoscopic remission; inflammatory bowel disease; mucosal healing; treatment goals; ulcerative colitis; INFLAMMATORY-BOWEL-DISEASE; QUALITY-OF-LIFE; C-REACTIVE PROTEIN; HEALING MAYO 0; FECAL CALPROTECTIN; MAINTENANCE THERAPY; HISTOLOGICAL REMISSION; CLINICAL REMISSION; 5-AMINOSALICYLIC ACID; ENDOSCOPIC REMISSION;

D O I：

10.1093/ibd/izac170

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

As the therapeutic targets in ulcerative colitis (UC) shift from control of symptoms to mucosal healing and prevention of disease complications like disability, colectomy, and cancer, the definition of remission has evolved. The current definition of clinical remission is variable and is determined by the clinical context in which it is being used. This results in skepticism and uncertainty about the true meaning of the term "clinical remission." In this review, the authors reexamine the definition of clinical remission and propose a novel approach to define remission in UC. Lay Summary The current definition of clinical remission in ulcerative colitis (UC) is variable and is determined by the clinical context in which it is being used. In this review, the authors reexamine the definition of clinical remission in UC and propose a novel approach to define remission based on the parameter being assessed.

引用

页码：1317 / 1326

页数：10

共 106 条

[71] Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health [J].

Peyrin-Biroulet, Laurent ;

Cieza, Alarcos ;

Sandborn, William J. ;

Coenen, Michaela ;

Chowers, Yehuda ;

Hibi, Toshifumi ;

Kostanjsek, Nenad ;

Stucki, Gerold ;

Colombel, Jean-Frederic .

GUT, 2012, 61 (02) :241-247

[72] Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial cell alterations [J].

Planell, Nuria ;

Lozano, Juan J. ;

Mora-Buch, Rut ;

Masamunt, M. Carme ;

Jimeno, Mireya ;

Ordas, Ingrid ;

Esteller, Miriam ;

Ricart, Elena ;

Pique, Josep M. ;

Panes, Julian ;

Salas, Azucena .

GUT, 2013, 62 (07) :967-976

[73] Impact of Histological and Endoscopic Remissions on Clinical Recurrence and Recurrence-free Time in Ulcerative Colitis [J].

Ponte, Ana ;

Pinho, Rolando ;

Fernandes, Sonia ;

Rodrigues, Adelia ;

Alberto, Luis ;

Silva, Joao Carlos ;

Silva, Joana ;

Rodrigues, Jaime ;

Sousa, Mafalda ;

Silva, Ana Paula ;

Proenca, Luisa ;

Freitas, Teresa ;

Leite, Sonia ;

Carvalho, Joao .

INFLAMMATORY BOWEL DISEASES, 2017, 23 (12) :2238-2244

[74] COATED MESALAZINE (5-AMINOSALICYLIC ACID) VERSUS SULPHASALAZINE IN THE TREATMENT OF ACTIVE ULCERATIVE-COLITIS - A RANDOMIZED TRIAL [J].

RACHMILEWITZ, D .

BMJ-BRITISH MEDICAL JOURNAL, 1989, 298 (6666) :82-86

[75] Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trial [J].

Reinisch, Walter ;

Sandborn, William J. ;

Hommes, Daniel W. ;

D'Haens, Geert ;

Hanauer, Stephen ;

Schreiber, Stefan ;

Panaccione, Remo ;

Fedorak, Richard N. ;

Tighe, Mary Beth ;

Huang, Bidan ;

Kampman, Wendy ;

Lazar, Andreas ;

Thakkar, Roopal .

GUT, 2011, 60 (06) :780-787

[76] ACG Clinical Guideline: Ulcerative Colitis in Adults [J].

Rubin, David T. ;

Ananthakrishnan, Ashwin N. ;

Siegel, Corey A. ;

Sauer, Bryan G. ;

Long, Millie D. .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2019, 114 (03) :384-413

[77] Infliximab for induction and maintenance therapy for ulcerative colitis [J].

Rutgeerts, P ;

Sandborn, WJ ;

Feagan, BG ;

Reinisch, W ;

Olson, A ;

Johanns, J ;

Travers, S ;

Rachmilewitz, D ;

Hanauer, SB ;

Lichtenstein, GR ;

de Villiers, WJS ;

Present, D ;

Sands, BE ;

Colombel, JF .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (23) :2462-2476

[78] Efficacy of Upadacitinib in a Randomized Trial of Patients With Active Ulcerative Colitis [J].

Sandborn, William J. ;

Ghosh, Subrata ;

Panes, Julian ;

Schreiber, Stefan ;

D'Haens, Geert ;

Tanida, Satoshi ;

Siffledeen, Jesse ;

Enejosa, Jefferey ;

Zhou, Wen ;

Othman, Ahmed A. ;

Huang, Bidan ;

Higgins, Peter D. R. .

GASTROENTEROLOGY, 2020, 158 (08) :2139-+

[79] Deep Remission With Vedolizumab in Patients With Moderately to Severely Active Ulcerative Colitis: A GEMINI 1 post hoc Analysis [J].

Sandborn, William J. ;

Colombel, Jean-Frederic ;

Panaccione, Remo ;

Dulai, Parambir S. ;

Rosario, Maria ;

Cao, Charlie ;

Barocas, Morris ;

Lasch, Karen .

JOURNAL OF CROHNS & COLITIS, 2019, 13 (02) :172-181

[80] Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis [J].

Sandborn, William J. ;

Su, Chinyu ;

Sands, Bruce E. ;

D'Haens, Geert R. ;

Vermeire, Severine ;

Schreiber, Stefan ;

Danese, Silvio ;

Feagan, Brian G. ;

Reinisch, Walter ;

Niezychowski, Wojciech ;

Friedman, Gary ;

Lawendy, Nervin ;

Yu, Dahong ;

Woodworth, Deborah ;

Mukherjee, Arnab ;

Zhang, Haiying ;

Healey, Paul ;

Panes, Julian .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (18) :1723-1736

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