Anti-IAV indole-diterpenoids from the marine-derived fungus Penicillium citrinum

被引：9
|
作者：
Pang, Sen [1 ]
Guo, Zhi-Gang [1 ]
Wang, Li [1 ]
Guo, Qing-Feng [1 ]
Cao, Fei [1 ,2 ]
机构：
[1] Huanghe Sci & Technol Coll, Zhengzhou, Peoples R China
[2] Hebei Univ, Coll Pharmaceut Sci, Baoding, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 04期
关键词：
marine-derived fungus; Penicillium citrinum; indole-diterpenoid; absolute configuration; influenza A virus; NATURAL-PRODUCTS;
D O I：
10.1080/14786419.2022.2078820
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new indole-diterpenoid, penijanthine E (1), and a known analogue (2), were obtained from the PDB culture of the marine-derived fungus Penicillium citrinum ZSS-9. The absolute configuration of 1 was elucidated by calculated TDDFT ECD and DP4plus calculations. The absolute configuration of 2 was confirmed by single-crystal X-ray diffraction analysis and TDDFT ECD calculations. Compounds 1 and 2 showed antiviral activity against influenza A virus (IAV) of A/WSN/33(H1N1) and A/PR/8/34(H1N1) strains with IC50 values ranging from 12.6 to 46.8 mu M.
引用
收藏
页码：586 / 591
页数：6
相关论文
共 50 条
  • [41] Lactone Derivatives from the Marine-Derived Fungus Penicillium sp PSU-F44
    Trisuwan, Kongkiat
    Rukachaisirikul, Vatcharin
    Sukpondma, Yaowapa
    Phongpaichit, Souwalak
    Preedanon, Sita
    Sakayaroj, Jariya
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57 (10) : 1100 - 1102
  • [42] Griseusin C, a novel quinone derivative from a marine-derived fungus Penicillium sp.
    Li, Xiang
    Zheng, Yinan
    Sattler, Isabel
    Lin, Wenhan
    ARCHIVES OF PHARMACAL RESEARCH, 2006, 29 (11) : 942 - 945
  • [43] A New Deoxyisoaustamide Derivative from the Marine-derived Fungus Penicillium sp JF-72
    Tran Hong Quang
    Lee, Dong-Sung
    Sohn, Jae Hak
    Kim, Youn-Chul
    Oh, Hyuncheol
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2013, 34 (10) : 3109 - 3112
  • [44] New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp.
    Ren, Jinwei
    Huo, Ruiyun
    Liu, Gaoran
    Liu, Ling
    MARINE DRUGS, 2021, 19 (04)
  • [45] New Verrucosidin Derivatives from the Marine-Derived Fungus Penicillium sp XL-01
    Xu, Yan
    Zhang, Miao
    Liu, Qing-Ai
    Hu, Lian-Dong
    Li, Wan
    Zhu, Hua-Jie
    Liu, Li
    Cao, Fei
    NATURAL PRODUCT COMMUNICATIONS, 2018, 13 (10) : 1329 - 1332
  • [46] Proangiogenic penibishexahydroxanthone A from the marine-derived fungus Penicillium sp. ZZ486A
    Chen, Mengxuan
    Gui, Yuhan
    Zhu, Hongrui
    Zhang, Zhizhen
    Lin, Hou-Wen
    TETRAHEDRON LETTERS, 2019, 60 (20) : 1393 - 1396
  • [47] Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32
    Fan, Ya-Qin
    Li, Pei-Hai
    Chao, Ya-Xi
    Chen, Hao
    Du, Ning
    He, Qiu-Xia
    Liu, Ke-Chun
    MARINE DRUGS, 2015, 13 (10) : 6489 - 6504
  • [48] ANTIMICROBIAL METABOLITES FROM A MARINE-DERIVED FUNGUS
    Maarisit, Wilmar
    Ueda, Katsuhiro
    INDONESIAN JOURNAL OF PHARMACY, 2013, 24 (03): : 163 - 169
  • [49] Secondary metabolites from Antarctic marine-derived fungus Penicillium crustosum HDN153086
    Liu, Cong-Cong
    Zhang, Zhen-Zhen
    Feng, Yan-Yan
    Gu, Qian-Qun
    Li, De-Hai
    Zhu, Tian-Jiao
    NATURAL PRODUCT RESEARCH, 2019, 33 (03) : 414 - 419
  • [50] Hydrogenation of Halogenated 2′-Hydroxychalcones by Mycelia of Marine-Derived Fungus Penicillium raistrickii
    Iara Lisboa de Matos
    Marcia Nitschke
    André Luiz Meleiro Porto
    Marine Biotechnology, 2019, 21 : 430 - 439
12345