Anti-IAV indole-diterpenoids from the marine-derived fungus Penicillium citrinum

被引：9
|
作者：
Pang, Sen [1 ]
Guo, Zhi-Gang [1 ]
Wang, Li [1 ]
Guo, Qing-Feng [1 ]
Cao, Fei [1 ,2 ]
机构：
[1] Huanghe Sci & Technol Coll, Zhengzhou, Peoples R China
[2] Hebei Univ, Coll Pharmaceut Sci, Baoding, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 04期
关键词：
marine-derived fungus; Penicillium citrinum; indole-diterpenoid; absolute configuration; influenza A virus; NATURAL-PRODUCTS;
D O I：
10.1080/14786419.2022.2078820
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new indole-diterpenoid, penijanthine E (1), and a known analogue (2), were obtained from the PDB culture of the marine-derived fungus Penicillium citrinum ZSS-9. The absolute configuration of 1 was elucidated by calculated TDDFT ECD and DP4plus calculations. The absolute configuration of 2 was confirmed by single-crystal X-ray diffraction analysis and TDDFT ECD calculations. Compounds 1 and 2 showed antiviral activity against influenza A virus (IAV) of A/WSN/33(H1N1) and A/PR/8/34(H1N1) strains with IC50 values ranging from 12.6 to 46.8 mu M.
引用
收藏
页码：586 / 591
页数：6
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