Antimicrobial resistance genetic determinants and susceptibility profile of Pseudomonas aeruginosa isolated from clinical samples in a tertiary hospital in Ogun State, Nigeria

被引:1
作者
Adeyelu, Oluwatoyin Olawunmi [1 ]
Essien, Edidiong Nkiruka [2 ]
Adebote, Valentine [3 ]
Ajayi, Abraham [4 ]
Essiet, Utibeima Udo [4 ]
Adeleye, Adeyemi Isaac [5 ]
Smith, Stella Ifeanyi [4 ,6 ]
机构
[1] Univ Lagos Akoka, Dept Microbiol, Akoka, Nigeria
[2] Univ Illinois, Coll Med Rockford, Rockford, IL USA
[3] Covenant Univ, Coll Sci & Technol, Dept Biol Sci, Ota, Ogun, Nigeria
[4] Nigerian Inst Med Res, Mol Biol & Biotechnol Dept, Lagos, Nigeria
[5] Univ Lagos, Dept Microbiol, Akoka, Nigeria
[6] Mt Top Univ, Dept Biol Sci, Makogi Oba, Ogun, Nigeria
关键词
antibiotic resistance; integrons; plasmids; Pseudomonas aeruginosa; replicon type; CARBAPENEM-RESISTANT;
D O I
10.1093/trstmh/trae012
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background Genetic determinants are known to promote antibiotic resistance through horizontal gene transfer.Methods We molecularly characterized integrons, plasmid replicon types and metallo-beta-lactamase-encoding genes of 38 Pseudomonas aeruginosa strains isolated from clinical samples.Results The P. aeruginosa isolates displayed high resistance (97.4%) to beta-lactams. Seventeen (44.74%) of them possessed plasmids. Of the 17 isolates that possessed plasmids, 11 (64.7%) of them harboured IncFIA plasmid replicon type, while 6 (35.3%), 5 (29.4%) and 5 (29.4%) were of the IncFIB, IncF and IncW types, respectively. The intI1 gene was detected in 19 (50%) of the isolates. The blaNDM-A, blaNDM-B and blaVIM genes were detected in 14 (35.9%), 4 (10.3%) and 5 (12.8%) of the isolates, respectively.Conclusions High resistance to beta-lactams was observed among P. aeruginosa strains of clinical origin in this study. They possessed transmissible genetic elements indicating the potential for continuous dissemination, thus continuous surveillance is advocated.
引用
收藏
页码:474 / 476
页数:3
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