The glymphatic system in migraine and other headaches

被引：18

作者：

Vittorini, Maria Grazia ^{[1
]}

Sahin, Aysenur ^{[2
]}

Trojan, Antonin ^{[3
]}

Yusifli, Sevil ^{[4
]}

Alashvili, Tamta ^{[5
]}

Bonifacio, Goncalo V. ^{[6
]}

Paposhvili, Ketevan ^{[7
]}

Tischler, Viktoria ^{[8
]}

Lampl, Christian ^{[8
]}

Sacco, Simona ^{[1
]}

机构：

[1] Univ Laquila, Dept Biotechnol & Appl Clin Sci, Laquila, Italy

[2] Ali Aydinlar Univ, Fac Med Acibadem Mehmet, Istanbul, Turkiye

[3] Strakonice Hosp, Dept Neurol, Strakonice, Czech Republic

[4] Istanbul Univ, Fac Med, Istanbul, Turkiye

[5] New Vis Univ Hosp, Dept Internal Med, Tbilisi, Georgia

[6] Hosp Sao Bernardo, Dept Neurol, Setubal, Portugal

[7] Tbilisi State Med Univ, Dept Neurol, Tbilisi, Georgia

[8] Konventhospital Barmherzige Bruder Linz, Dept Neurol, Linz, Austria

来源：

JOURNAL OF HEADACHE AND PAIN | 2024年 / 25卷 / 01期

关键词：

Glymphatic system; Perivascular space; Cerebrospinal fluid; Neurological disorders; Migraine; Headache; Cortical spreading depression; CGRP; DTI-ALPS; CORTICAL SPREADING DEPRESSION; ENLARGED PERIVASCULAR SPACES; IDIOPATHIC INTRACRANIAL HYPERTENSION; CEREBROSPINAL-FLUID; MENINGEAL NOCICEPTORS; POTENTIAL ROLE; BRAIN; CLEARANCE; PATHWAY; DEPOLARIZATION;

D O I：

10.1186/s10194-024-01741-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Glymphatic system is an emerging pathway of removing metabolic waste products and toxic solutes from the brain tissue. It is made of a network of perivascular spaces, filled in cerebrospinal and interstitial fluid, encompassing penetrating and pial vessels and communicating with the subarachnoid space. It is separated from vessels by the blood brain barrier and from brain tissue by the endfeet of the astrocytes rich in aquaporin 4, a membrane protein which controls the water flow along the perivascular space. Animal models and magnetic resonance (MR) studies allowed to characterize the glymphatic system function and determine how its impairment could lead to numerous neurological disorders (e.g. Alzheimer's disease, stroke, sleep disturbances, migraine, idiopathic normal pressure hydrocephalus). This review aims to summarize the role of the glymphatic system in the pathophysiology of migraine in order to provide new ways of approaching to this disease and to its therapy.

引用

页数：12

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