Healthy Lifestyle and Cognition in Older Adults With Common Neuropathologies of Dementia

被引:21
|
作者
Dhana, Klodian [1 ,2 ,6 ]
Agarwal, Puja [2 ,3 ]
James, Bryan D. [2 ,3 ]
Leurgans, Sue E. [3 ,4 ]
Rajan, Kumar B. [1 ,2 ]
Aggarwal, Neelum T. [3 ,4 ]
Barnes, Lisa L. [3 ,4 ]
Bennett, David A. [3 ,4 ]
Schneider, Julie A. [3 ,4 ,5 ]
机构
[1] Rush Univ, Med Ctr, Rush Inst Hlth Aging, Chicago, IL USA
[2] Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL USA
[3] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL USA
[4] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL USA
[5] Rush Univ, Med Ctr, Dept Pathol, Chicago, IL USA
[6] Rush Univ, Med Ctr, 1700 W Van Buren St,Ste 245, Chicago, IL 60612 USA
基金
美国国家卫生研究院;
关键词
ALZHEIMERS-DISEASE; IMPAIRMENT; DECLINE; POPULATION; MEMORY;
D O I
10.1001/jamaneurol.2023.5491
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Importance A healthy lifestyle is associated with better cognitive functioning in older adults, but whether this association is independent of the accumulation of dementia-related pathologies in the brain is uncertain. Objective To determine the role of postmortem brain pathology, including beta-amyloid load, phosphorylated tau tangles, cerebrovascular pathology, and other brain pathologies, in the association between lifestyle and cognition proximate to death. Design, Setting, and Participants This cohort study used data from the Rush Memory and Aging Project, a longitudinal clinical-pathologic study with autopsy data from 1997 to 2022 and up to 24 years of follow-up. Participants included 754 deceased individuals with data on lifestyle factors, cognitive testing proximate to death, and a complete neuropathologic evaluation at the time of these analyses. Data were analyzed from January 2023 to June 2023. Exposures A healthy lifestyle score was developed based on self-reported factors, including noncurrent smoking, at least 150 minutes of physical activity per week, limiting alcohol consumption, a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet score higher than 7.5, and a late-life cognitive activity score higher than 3.2. The lifestyle score ranges from 0 to 5, with higher scores reflecting a healthier lifestyle. Main Outcomes and Measures The global cognitive score was derived from a battery of nineteen standardized tests. Brain pathology measures included beta-amyloid load, phosphorylated tau tangles, global Alzheimer disease pathology, vascular brain pathologies, Lewy body, hippocampal sclerosis, and TAR DNA-binding protein 43. Results Of 586 included decedents, 415 (70.8%) were female, 171 (29.2%) were male, and the mean (SD) age at death was 90.9 (6.0) years. Higher lifestyle score was associated with better global cognitive functioning proximate to death. In the multivariable-adjusted model, a 1-point increase in lifestyle score was associated with 0.216 (SE = 0.036, P < .001) units higher in global cognitive scores. Neither the strength nor the significance of the association changed substantially when common dementia-related brain pathologies were included in the multivariable-adjusted models. The beta estimate after controlling for the beta-amyloid load was 0.191 (SE = 0.035; P < .001). A higher lifestyle score was associated with lower beta-amyloid load in the brain (beta = -0.120; SE = 0.041; P = .003), and 11.6% of the lifestyle-cognition association was estimated through beta-amyloid load. Conclusions and Relevance This study found that in older adults, a healthy lifestyle may provide a cognitive reserve to maintain cognitive abilities independently of common neuropathologies of dementia.
引用
收藏
页码:233 / 239
页数:7
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