Microbubbles: Revolutionizing Biomedical Applications with Tailored Therapeutic Precision

被引:3
作者
Kumar, Mohit [1 ]
Kumar, Devesh [1 ]
Chopra, Shruti [1 ]
Mahmood, Syed [2 ]
Bhatia, Amit [1 ]
机构
[1] Maharaja Ranjit Singh Punjab Tech Univ MRSPTU, Dept Pharmaceut Sci & Technol, Bathinda 151001, Punjab, India
[2] Univ Malaya, Fac Pharm, Dept Pharmaceut Technol, Kuala Lumpur 50603, Malaysia
关键词
Microbubble; drug delivery; gene delivery; ligands; ultrasound; dynamic tool; ULTRASOUND CONTRAST AGENTS; DRUG-DELIVERY; GENE DELIVERY; TARGETED DELIVERY; LOADED MICROBUBBLES; CAVITATION; ECHOCARDIOGRAPHY; BRAIN; OPACIFICATION; OPTIMIZATION;
D O I
10.2174/0113816128282478231219044000
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: Over the past ten years, tremendous progress has been made in microbubble-based research for a variety of biological applications. Microbubbles emerged as a compelling and dynamic tool in modern drug delivery systems. They are employed to deliver drugs or genes to targeted regions of interest, and then ultrasound is used to burst the microbubbles, causing site-specific delivery of the bioactive materials.Objective: The objective of this article is to review the microbubble compositions and physiochemical characteristics in relation to the development of innovative biomedical applications, with a focus on molecular imaging and targeted drug/gene delivery.Methods: The microbubbles are prepared by using various methods, which include cross-linking polymerization, emulsion solvent evaporation, atomization, and reconstitution. In cross-linking polymerization, a fine foam of the polymer is formed, which serves as a bubble coating agent and colloidal stabilizer, resulting from the vigorous stirring of a polymeric solution. In the case of emulsion solvent evaporation, there are two solutions utilized in the production of microbubbles. In atomization and reconstitution, porous spheres are created by atomising a surfactant solution into a hot gas. They are encapsulated in primary modifier gas. After the addition of the second gas or gas osmotic agent, the package is placed into a vial and sealed after reconstituting with sterile saline solution.Results: Microbubble-based drug delivery is an innovative approach in the field of drug delivery that utilizes microbubbles, which are tiny gas-filled bubbles, act as carriers for therapeutic agents. These microbubbles can be loaded with drugs, imaging agents, or genes and then guided to specific target sites.Conclusion: The potential utility of microbubbles in biomedical applications is continually growing as novel formulations and methods. The versatility of microbubbles allows for customization, tailoring the delivery system to various medical applications, including cancer therapy, cardiovascular treatments, and gene therapy.
引用
收藏
页码:3532 / 3545
页数:14
相关论文
共 133 条
  • [1] Usefulness of harmonic imaging for left ventricular opacification and endocardial border delineation by Optison
    Al-Mansour, HA
    Mulvagh, SL
    Pumper, GM
    Klarich, KW
    Foley, DA
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2000, 85 (06) : 795 - +
  • [2] Effects on P-Glycoprotein Expression after Blood-Brain Barrier Disruption Using Focused Ultrasound and Microbubbles
    Aryal, Muna
    Fischer, Krisztina
    Gentile, Caroline
    Gitto, Salvatore
    Zhang, Yong-Zhi
    McDannold, Nathan
    [J]. PLOS ONE, 2017, 12 (01):
  • [3] CUTE-CV: A Prospective Study of Enhanced Left Atrial Appendage Visualization with Microbubble Contrast Agent Use during Transesophageal Echocardiography Guided Cardioversion
    Bernier, Mathieu
    Abdelmoneim, Sahar S.
    Moir, W. Stuart
    Rain, Susan J. Eifert
    Chandrasekaran, Krishnaswamy
    Ammash, Naser M.
    Mulvagh, Sharon L.
    [J]. ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 2013, 30 (09): : 1091 - 1097
  • [4] Bhattacharya S., 2017, Biomed. J. Sci. Tech. Res
  • [5] Preparation of polymeric microbubbles: formulation studies and product characterisation
    Bjerknes, K
    Sontum, PC
    Smistad, G
    Agerkvist, I
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 158 (02) : 129 - 136
  • [6] Bjorn T.G., 2002, Inst Med, V16, P292
  • [7] Lateral phase separation in lipid-coated microbubbles
    Borden, MA
    Martinez, GV
    Ricker, J
    Tsvetkova, N
    Longo, M
    Gillies, RJ
    Dayton, PA
    Ferrara, KW
    [J]. LANGMUIR, 2006, 22 (09) : 4291 - 4297
  • [8] On the Shape of Surface Nanobubbles
    Borkent, Bram M.
    de Beer, Sissi
    Mugele, Frieder
    Lohse, Detlef
    [J]. LANGMUIR, 2010, 26 (01) : 260 - 268
  • [9] Tethering functional ligands onto shell of ultrasound active polymeric microbubbles
    Cavalieri, F
    El Hamassi, A
    Chiessi, E
    Paradossi, G
    Villa, R
    Zaffaroni, N
    [J]. BIOMACROMOLECULES, 2006, 7 (02) : 604 - 611
  • [10] Chaplin M., 2019, Biomed J Sci Tech Res, V1, P2017