A new thiosemicarbazone and its 3d metal complexes: Synthetic, structural, and antioxidant studies

被引：2
作者：
Graur, Ianina [1 ]
Bespalova, Tatiana [1 ]
Graur, Vasilii [1 ]
Tsapkov, Victor [1 ]
Garbuz, Olga [1 ]
Melnic, Elena [2 ]
Bourosh, Pavlina [2 ]
Gulea, Aurelian [1 ]
机构：
[1] Moldova State Univ, Lab Adv Mat Biopharmaceut & Tech, Alexei Mateevici St 60, Kishinev 2009, Moldova
[2] Moldova State Univ, Inst Appl Phys, Lab Phys Methods Solid State Invest Tadeusz Malino, Kishinev, Moldova
来源：
JOURNAL OF CHEMICAL RESEARCH | 2023年 / 47卷 / 06期
关键词：
3d metal complex; amide; antioxidants; pyruvic acid; thiosemicarbazone; PYRUVIC-ACID; BIOLOGICAL-PROPERTIES; COPPER(II) COMPLEXES; CRYSTAL; DERIVATIVES;
D O I：
10.1177/17475198231216422
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
2-[1-Oxo-1-(piperidin-1-yl)propan-2-ylidene]-N-(prop-2-en-1-yl)hydrazinecarbothioamide (HL) and its six coordination compounds [Cu(L)X] (X = Cl- (1), NO3- (2)), [Cu(A)(L)NO3](A = 1,10-Phen (3), 2,2 '-Bpy (4)), [Ni(HL)2](NO3)2 (5), and [Fe(L)2]Cl (6) are synthesized and characterized by elemental analysis, Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and single-crystal X-ray crystallography. Uncoordinated thiosemicarbazone HL shows higher antioxidant activity against 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS+center dot) cation radicals compared with most of the other complexes. Complex 5 is the most active and its activity exceeds that of HL and is close to that of trolox, which is used in medicine as an antioxidant. The introduction of N-heteroaromatic bases (1,10-phenanthroline and 2,2 '-bipyridine) into the inner sphere of the complex [Cu(L)NO3] did not lead to an increase in antioxidant activity.
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页数：8
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