1-Aryl-4-(2-oxoalkylsulfanyl)-2,3(5H)-benzodiazepines: synthesis and thiophene ring annulation to 1,2-diazepine core

被引：0

作者：

Bohdan, Natalia M. ^{[1
]}

Stepanova, Diana S. ^{[1
]}

Suikov, Serhii Yu. ^{[1
]}

Popov, Vadim Yu. ^{[2
]}

Ishkov, Yuri V. ^{[3
]}

Bohza, Serhii L. ^{[1
,2
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Organ Chem, 5 Akademika Kukharya St, UA-02094 Kiev, Ukraine

[2] Natl Acad Sci Ukraine, L M Litvinenko Inst Phys Organ Chem & Coal Chem, 50 Kharkivske Rd, UA-02155 Kiev, Ukraine

[3] Odesa I I Mechnikov Natl Univ, 2 Dvoryanskaya St, UA-65082 Odesa, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2023年 / 59卷 / 6-7期

关键词：

2,3-benzodiazepine; thione; alkylation; cyclization; NMR analysis; synthesis; AMPA RECEPTOR ANTAGONISTS; ROUTE;

D O I：

10.1007/s10593-023-03223-w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Aryl-2-[(1-aryl-5H-2,3-benzodiazepin-4-yl)sulfanyl]ethanones were obtained by the alkylation of 1-aryl-2,3-benzodiazepine-4(3H,5H)-thiones with 1-aryl-2-bromoethanones. A reaction for the annulation of the thiophene core to the 1,2-diazepine ring as a result of intramolecular cyclization involving a 4-aroylmethylsulfanyl substituent and C(4)-C(5) bond of diazepine was developed. Derivatives of a new thieno[2,3-d][2,3]benzodiazepine heterocyclic system were synthesized.

引用

页码：508 / 511

页数：4

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