Cordyceps cicadae polysaccharides alleviate hyperglycemia by regulating gut microbiota and its mmetabolites in high-fat diet/streptozocin-induced diabetic mice
被引:9
作者:
Wang, Yanan
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Xuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R China
Wang, Yanan
[1
]
Ni, Zaizhong
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Xuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R China
Ni, Zaizhong
[1
]
Li, Jinting
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Xuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R China
Li, Jinting
[1
]
Shao, Ying
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Xuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R China
Shao, Ying
[1
]
Yong, Yidan
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Xuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R China
Yong, Yidan
[1
]
Lv, Wendi
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Xuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R China
Lv, Wendi
[1
]
Zhang, Simeng
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Xuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R China
Zhang, Simeng
[1
]
Fu, Tingwei
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Xuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R China
Fu, Tingwei
[1
]
Chen, Anhui
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Xuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R China
Chen, Anhui
[1
]
机构:
[1] Xuzhou Univ Technol, Coll Food & Bioengn, Xuzhou, Jiangsu, Peoples R China
IntroductionThe polysaccharides found in Cordyceps cicadae (C. cicadae) have received increasing academic attention owing to their wide variety of therapeutic activities. MethodsThis study evaluated the hypoglycemic, antioxidant, and anti-inflammatory effects of polysaccharides from C. cicadae (CH-P). In addition, 16s rDNA sequencing and untargeted metabolomics analysis by liquid chromatography-mass spectrometry (LC-MS) were used to estimate the changes and regulatory relationships between gut microbiota and its metabolites. The fecal microbiota transplantation (FMT) was used to verify the therapeutic effects of microbial remodeling. ResultsThe results showed that CH-P treatment displayed hypoglycemic, antioxidant, and anti-inflammatory effects and alleviated tissue damage induced by diabetes. The CH-P treatment significantly reduced the Firmicutes/Bacteroidetes ratio and increased the abundance of Bacteroides, Odoribacter, Alloprevotella, Parabacteroides, Mucispirillum, and significantly decreased the abundance of Helicobacter and Lactobacillus compared to the diabetic group. The alterations in the metabolic pathways were mostly related to amino acid biosynthesis and metabolic pathways (particularly those involving tryptophan) according to the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Correlation analysis showed that Bacteroides, Odoribacter, Alloprevotella, Parabacteroides, and Mucispirillum were positively correlated with indole and its derivatives, such as 5-hydroxyindole-3-acetic acid. Indole intervention significantly improved hyperglycemic symptoms and insulin sensitivity, and increased the secretion of glucagon-like peptide-1 (GLP-1) in diabetic mice. FMT reduced blood glucose levels, improved glucose tolerance, and increased insulin sensitivity in diabetic mice. However, FMT did not significantly improve GLP-1 levels. DiscussionThis indicates that C. cicadae polysaccharides alleviate hyperglycemia by regulating the production of metabolites other than indole and its derivatives by gut microbiota. This study provides an important reference for the development of novel natural products.
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INRA, Micalis UMR1319, Jouy En Josas, France
AgroParisTech, Jouy En Josas, FranceINRA, Micalis UMR1319, Jouy En Josas, France
Agus, Allison
Planchais, Julien
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INRA, Micalis UMR1319, Jouy En Josas, France
AgroParisTech, Jouy En Josas, FranceINRA, Micalis UMR1319, Jouy En Josas, France
Planchais, Julien
Sokol, Harry
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h-index: 0
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INRA, Micalis UMR1319, Jouy En Josas, France
AgroParisTech, Jouy En Josas, France
Sorbonne Univ, PSL Res Univ, Ecole Normale Super,Lab Biomol,LBM, CNRS,INSERM,Hop St Antoine,AP HP,Gastroenterol De, 184 Rue Faubourg St Antoine, F-75005 Paris, FranceINRA, Micalis UMR1319, Jouy En Josas, France
机构:
Sorbonne Univ, INSERM, Nutr & Obes Syst Approaches NutriOMics Res Unit, Paris, France
Hop La Pitie Salpetriere, AP HP, Nutr Dept, F-75013 Paris, France
Univ Amsterdam, Amsterdam UMC, Locat AMC, Amsterdam, Netherlands
Univ Amsterdam, VUMC, Dept Internal & Vasc Med, Amsterdam, NetherlandsSorbonne Univ, INSERM, Nutr & Obes Syst Approaches NutriOMics Res Unit, Paris, France
Aron-Wisnewsky, Judith
Clement, Karine
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Sorbonne Univ, INSERM, Nutr & Obes Syst Approaches NutriOMics Res Unit, Paris, France
Hop La Pitie Salpetriere, AP HP, Nutr Dept, F-75013 Paris, FranceSorbonne Univ, INSERM, Nutr & Obes Syst Approaches NutriOMics Res Unit, Paris, France
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Beijing Univ Chinese Med, Beijing, Peoples R China
Beijing Univ Chinese Med, Key Lab Chinese Internal Med, Minist Educ, Beijing Dongzhimen Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Cai, Yuzi
Feng, Zhendong
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Beijing Tradit Chinese Med Hosp, Dept Nephropathy, Pinggu Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Feng, Zhendong
Jia, Qi
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Beijing Univ Chinese Med, Dongfang Hosp, Dept Nephropathy, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Jia, Qi
Guo, Jing
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Beijing Univ Chinese Med, Beijing, Peoples R China
Beijing Univ Chinese Med, Key Lab Chinese Internal Med, Minist Educ, Beijing Dongzhimen Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Guo, Jing
Zhang, Pingna
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Beijing Univ Chinese Med, Beijing, Peoples R China
Beijing Univ Chinese Med, Key Lab Chinese Internal Med, Minist Educ, Beijing Dongzhimen Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Zhang, Pingna
Zhao, Qihan
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Beijing Univ Chinese Med, Beijing, Peoples R China
Beijing Univ Chinese Med, Key Lab Chinese Internal Med, Minist Educ, Beijing Dongzhimen Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Zhao, Qihan
Wang, Yao Xian
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Beijing Univ Chinese Med, Beijing, Peoples R China
Beijing Univ Chinese Med, Key Lab Chinese Internal Med, Minist Educ, Beijing Dongzhimen Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Wang, Yao Xian
Liu, Yu Ning
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Beijing Univ Chinese Med, Dept Endocrinol Nephropathy, Dongzhimen Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Liu, Yu Ning
Liu, Wei Jing
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Beijing Univ Chinese Med, Key Lab Chinese Internal Med, Minist Educ, Beijing Dongzhimen Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
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Duke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27710 USA
Duke Univ, Med Ctr, Duke Mol Physiol Inst, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Med, Endocrinol & Metab Div, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27708 USADuke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27710 USA
Campbell, Jonathan E.
Newgard, Christopher B.
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Duke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27710 USA
Duke Univ, Med Ctr, Duke Mol Physiol Inst, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Med, Endocrinol & Metab Div, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27708 USADuke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27710 USA
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Jiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R China
Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Jiangsu, Peoples R ChinaJiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R China
Deng, Chao
Shang, Jingying
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Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Jiangsu, Peoples R ChinaJiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R China
Shang, Jingying
Fu, Haitian
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Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Jiangsu, Peoples R ChinaJiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R China
Fu, Haitian
Chen, Jingxiao
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Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Jiangsu, Peoples R ChinaJiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R China
Chen, Jingxiao
Liu, Hanying
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Jiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R ChinaJiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R China
Liu, Hanying
Chen, Jinghua
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Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Jiangsu, Peoples R ChinaJiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R China
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INRA, Micalis UMR1319, Jouy En Josas, France
AgroParisTech, Jouy En Josas, FranceINRA, Micalis UMR1319, Jouy En Josas, France
Agus, Allison
Planchais, Julien
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INRA, Micalis UMR1319, Jouy En Josas, France
AgroParisTech, Jouy En Josas, FranceINRA, Micalis UMR1319, Jouy En Josas, France
Planchais, Julien
Sokol, Harry
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h-index: 0
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INRA, Micalis UMR1319, Jouy En Josas, France
AgroParisTech, Jouy En Josas, France
Sorbonne Univ, PSL Res Univ, Ecole Normale Super,Lab Biomol,LBM, CNRS,INSERM,Hop St Antoine,AP HP,Gastroenterol De, 184 Rue Faubourg St Antoine, F-75005 Paris, FranceINRA, Micalis UMR1319, Jouy En Josas, France
机构:
Sorbonne Univ, INSERM, Nutr & Obes Syst Approaches NutriOMics Res Unit, Paris, France
Hop La Pitie Salpetriere, AP HP, Nutr Dept, F-75013 Paris, France
Univ Amsterdam, Amsterdam UMC, Locat AMC, Amsterdam, Netherlands
Univ Amsterdam, VUMC, Dept Internal & Vasc Med, Amsterdam, NetherlandsSorbonne Univ, INSERM, Nutr & Obes Syst Approaches NutriOMics Res Unit, Paris, France
Aron-Wisnewsky, Judith
Clement, Karine
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h-index: 0
机构:
Sorbonne Univ, INSERM, Nutr & Obes Syst Approaches NutriOMics Res Unit, Paris, France
Hop La Pitie Salpetriere, AP HP, Nutr Dept, F-75013 Paris, FranceSorbonne Univ, INSERM, Nutr & Obes Syst Approaches NutriOMics Res Unit, Paris, France
机构:
Beijing Univ Chinese Med, Beijing, Peoples R China
Beijing Univ Chinese Med, Key Lab Chinese Internal Med, Minist Educ, Beijing Dongzhimen Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Cai, Yuzi
Feng, Zhendong
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h-index: 0
机构:
Beijing Tradit Chinese Med Hosp, Dept Nephropathy, Pinggu Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Feng, Zhendong
Jia, Qi
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Beijing Univ Chinese Med, Dongfang Hosp, Dept Nephropathy, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Jia, Qi
Guo, Jing
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Beijing Univ Chinese Med, Beijing, Peoples R China
Beijing Univ Chinese Med, Key Lab Chinese Internal Med, Minist Educ, Beijing Dongzhimen Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Guo, Jing
Zhang, Pingna
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Beijing Univ Chinese Med, Beijing, Peoples R China
Beijing Univ Chinese Med, Key Lab Chinese Internal Med, Minist Educ, Beijing Dongzhimen Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Zhang, Pingna
Zhao, Qihan
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Beijing Univ Chinese Med, Beijing, Peoples R China
Beijing Univ Chinese Med, Key Lab Chinese Internal Med, Minist Educ, Beijing Dongzhimen Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Zhao, Qihan
Wang, Yao Xian
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Beijing Univ Chinese Med, Beijing, Peoples R China
Beijing Univ Chinese Med, Key Lab Chinese Internal Med, Minist Educ, Beijing Dongzhimen Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Wang, Yao Xian
Liu, Yu Ning
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Beijing Univ Chinese Med, Dept Endocrinol Nephropathy, Dongzhimen Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
Liu, Yu Ning
Liu, Wei Jing
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Beijing Univ Chinese Med, Key Lab Chinese Internal Med, Minist Educ, Beijing Dongzhimen Hosp, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Beijing, Peoples R China
机构:
Duke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27710 USA
Duke Univ, Med Ctr, Duke Mol Physiol Inst, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Med, Endocrinol & Metab Div, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27708 USADuke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27710 USA
Campbell, Jonathan E.
Newgard, Christopher B.
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h-index: 0
机构:
Duke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27710 USA
Duke Univ, Med Ctr, Duke Mol Physiol Inst, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Med, Endocrinol & Metab Div, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27708 USADuke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27710 USA
机构:
Jiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R China
Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Jiangsu, Peoples R ChinaJiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R China
Deng, Chao
Shang, Jingying
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Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Jiangsu, Peoples R ChinaJiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R China
Shang, Jingying
Fu, Haitian
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Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Jiangsu, Peoples R ChinaJiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R China
Fu, Haitian
Chen, Jingxiao
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Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Jiangsu, Peoples R ChinaJiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R China
Chen, Jingxiao
Liu, Hanying
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Jiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R ChinaJiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R China
Liu, Hanying
Chen, Jinghua
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Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Jiangsu, Peoples R ChinaJiangnan Univ, Wuxi Med Sch, Wuxi 214122, Peoples R China