Immunogenicity of NVX-CoV2373 heterologous boost against SARS-CoV-2 variants

被引：20

作者：

Lyke, Kirsten E. ^{[1
]}

Atmar, Robert L. ^{[2
,3
]}

Islas, Clara Dominguez ^{[4
]}

Posavad, Christine M. ^{[4
,5
]}

Deming, Meagan E. ^{[1
]}

Branche, Angela R. ^{[6
]}

Johnston, Christine ^{[4
,5
,7
]}

El Sahly, Hana M. ^{[2
,3
]}

Edupuganti, Srilatha ^{[8
,9
]}

Mulligan, Mark J. ^{[10
,11
]}

Jackson, Lisa A. ^{[12
]}

Rupp, Richard E. ^{[13
]}

Rostad, Christina A. ^{[14
,15
,16
]}

Coler, Rhea N. ^{[17
,18
]}

Backer, Martin ^{[19
,20
]}

Kottkamp, Angelica C. ^{[10
,11
]}

Babu, Tara M. ^{[7
]}

Dobrzynski, David ^{[6
]}

Martin, Judith M. ^{[21
]}

Brady, Rebecca C. ^{[22
]}

Frenck Jr, Robert W. ^{[22
]}

Rajakumar, Kumaravel ^{[21
]}

Kotloff, Karen ^{[1
]}

Rouphael, Nadine ^{[8
,9
]}

Szydlo, Daniel ^{[23
]}

PaulChoudhury, Rahul ^{[23
]}

Archer, Janet, I ^{[24
]}

Crandon, Sonja ^{[25
]}

Ingersoll, Brian ^{[23
]}

Eaton, Amanda ^{[26
]}

Brown, Elizabeth R. ^{[4
]}

McElrath, M. Juliana ^{[4
,7
]}

Neuzil, Kathleen M. ^{[1
]}

Stephens, David S. ^{[8
]}

Post, Diane J. ^{[25
]}

Lin, Bob C. ^{[27
]}

Serebryannyy, Leonid ^{[27
]}

Beigel, John H. ^{[25
]}

Montefiori, David C. ^{[26
,28
]}

Roberts, Paul C. ^{[25
]}

机构：

[1] Univ Maryland, Ctr Vaccine Dev & Global Hlth, Sch Med, Baltimore, MD 21201 USA

[2] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

[4] Fred Hutchinson Canc Ctr, Vaccine & Infect Dis Div, Seattle, WA USA

[5] Fred Hutchinson Canc Res Ctr, Dept Lab Med & Pathol, Seattle, WA USA

[6] Univ Rochester, Dept Med, Div Infect Dis, Rochester, NY USA

[7] Univ Washington, Dept Med, Seattle, WA USA

[8] Emory Univ, Dept Med, Sch Med, Atlanta, GA USA

[9] Emory Vaccine Ctr, Hope Clin, Atlanta, GA USA

[10] NYU Langone Vaccine Ctr, New York, NY USA

[11] NYU Grossman Sch Med, Dept Med, Div Infect Dis & Immunol, New York, NY USA

[12] Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA

[13] Univ Texas Med Branch, Sealy Inst Vaccine Sci, Galveston, TX USA

[14] Emory Univ, Dept Pediat, Sch Med, Atlanta, GA USA

[15] Emory Univ, Ctr Childhood Infect & Vaccines, Sch Med, Atlanta, GA USA

[16] Childrens Healthcare Atlanta, Atlanta, GA USA

[17] Univ Washington, Seattle Childrens Res Inst, Sch Med, Seattle, WA USA

[18] Univ Washington, Dept Pediat, Sch Med, Seattle, WA USA

[19] NYU Langone Hosp, Long Isl Vaccine Ctr Res Clin, Mineola, NY USA

[20] NYU Long Isl Sch Med, Dept Med, Div Infect Dis, Mineola, NY USA

[21] Univ Pittsburgh, Dept Pediat, Sch Med, Pittsburgh, PA USA

[22] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Div Infect Dis, Coll Med, Cincinnati, OH USA

[23] Fred Hutchinson Canc Res Ctr, Stat Ctr HIV AIDS Res & Prevent SCHARP, Seattle, WA USA

[24] FHI360, Durham, NC 27701 USA

[25] NIAID, Div Microbiol & Infect Dis, NIH, Bethesda, MD USA

[26] Duke Univ, Dept Surg, Med Ctr, Durham, NC USA

[27] NIAID, Vaccine Immunol Program, Vaccine Res Ctr, NIH, Bethesda, MD USA

[28] Duke Univ, Duke Human Vaccine Inst, Med Ctr, Durham, NC USA

来源：

NPJ VACCINES | 2023年 / 8卷 / 01期

基金：

美国国家卫生研究院;

关键词：

COVID-19; VACCINES; INTERIM RECOMMENDATIONS; IMMUNIZATION PRACTICES; ADVISORY-COMMITTEE; UNITED-STATES;

D O I：

10.1038/s41541-023-00693-z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

As part of a multicenter study evaluating homologous and heterologous COVID-19 booster vaccines, we assessed the magnitude, breadth, and short-term durability of binding and pseudovirus-neutralizing antibody (PsVNA) responses following a single booster dose of NVX-CoV2373 in adults primed with either Ad26.COV2.S, mRNA-1273, or BNT162b2 vaccines. NVX-CoV2373 as a heterologous booster was immunogenic and associated with no safety concerns through Day 91. Fold-rises in PsVNA titers from baseline (Day 1) to Day 29 were highest for prototypic D614G variant and lowest for more recent Omicron sub-lineages BQ.1.1 and XBB.1. Peak humoral responses against all SARS-CoV-2 variants were lower in those primed with Ad26.COV2.S than with mRNA vaccines. Prior SARS CoV-2 infection was associated with substantially higher baseline PsVNA titers, which remained elevated relative to previously uninfected participants through Day 91. These data support the use of heterologous protein-based booster vaccines as an acceptable alternative to mRNA or adenoviral-based COVID-19 booster vaccines. This trial was conducted under ClinicalTrials.gov: NCT04889209.

引用

页数：10

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