Case report: Bullous pemphigoid in HIV-1-positive patients: interplay or coincidence? A case series and review of the literature

被引:1
|
作者
Foerster, Yannick [1 ,2 ]
Sollfrank, Lukas [1 ,2 ]
Rechtien, Laura [1 ,2 ]
Harrer, Thomas [2 ,3 ]
Berking, Carola [1 ,2 ]
Sticherling, Michael [1 ,2 ]
机构
[1] Friedrich Alexander Univ Erlangen Nurnberg, Univ klinikum Erlangen, Dept Dermatol, Erlangen, Germany
[2] Deutsch Zent Immuntherapie, Erlangen, Germany
[3] Univ klinikum Erlangen, Dept Internal Med 3, Infect Dis & Immunodeficiency Sect, Erlangen, Germany
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词
bullous pemphigoid; HIV-1; aids; immune reconstitution inflammatory syndrome; iris; dupilumab; COVID-19; RECONSTITUTION INFLAMMATORY SYNDROME; IMMUNE RECONSTITUTION; ANTIRETROVIRAL THERAPY; HIV-1; INFECTION;
D O I
10.3389/fimmu.2023.1179294
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Bullous pemphigoid (BP) is an autoimmune inflammatory skin disease, mostly affecting the elderly population. Therefore, patients often have multiple comorbidities, but there is inconsistent data regarding the relationship between HIV-1 infection and BP, which has been rarely reported in combination. Herein, we describe three patients who presented with BP and concomitant HIV-1 infection that was well controlled with modern combined antiretroviral therapy. All patients received topical and oral corticosteroids. Depending on the individual severity, further add-on therapeutics, such as azathioprine, dapsone, doxycycline and the interleukin 4/13 antibody dupilumab, were added to the therapy regimen. All patients recovered from pruritic skin lesions and blistering. The cases are further discussed in the context of the current study landscape. In conclusion, HIV-1 infection shifts the cytokine profile from T-helper type 1 (TH1) towards T-helper type 2 (TH2), resulting in the excessive secretion of distinct cytokines, such as interleukin 4 (IL-4) and interleukin 10 (IL-10). With IL-4 being a main driver in the pathogenesis of BP, HIV-1-positive patients may benefit greatly from targeting IL-4 with monoclonal antibodies.
引用
收藏
页数:6
相关论文
共 50 条
  • [21] Bullous pemphigoid in a chronic renal allograft rejection patient: a case report and review of the literature
    Liaw, Tse-Yuan
    Hwang, Shang-Jyh
    Hwang, Daw-Yang
    Chen, Gwo-Shing
    DERMATOLOGICA SINICA, 2011, 29 (03) : 94 - 97
  • [22] Concomitant systemic lupus erythematosus and HIV: Case series and literature review
    Mody, Girish M.
    Patel, Neeta
    Budhoo, Amritha
    Dubula, Thozama
    SEMINARS IN ARTHRITIS AND RHEUMATISM, 2014, 44 (02) : 186 - 194
  • [23] Bipolar Patients and Bullous Pemphigoid after Risperidone Long-Acting Injectable: A Case Report and a Review of the Literature
    Fabrazzo, Michele
    Boccardi, Mariangela
    Cipolla, Salvatore
    Galiero, Raffaele
    Tucci, Claudia
    Perris, Francesco
    Di Caprio, Ester Livia
    Catapano, Francesco
    Sasso, Ferdinando Carlo
    BRAIN SCIENCES, 2021, 11 (11)
  • [24] Posterior reversible encephalopathy syndrome in HIV-positive patients: a case report and literature review
    Pool, Erica R. M.
    Porte, Michael
    Durham, Nigel
    Urwin, Sue
    Laboi, Paul
    Martin, Fabiola
    INTERNATIONAL JOURNAL OF STD & AIDS, 2018, 29 (09) : 937 - 941
  • [25] Successful Treatment of Bullous Pemphigoid Lesions by Berberine Stamp Therapy: A Case Report and Literature Review
    Cheng, Linyan
    Wang, Yi
    Lu, Hanzhi
    Guo, Wanjun
    Yan, Ge
    Zhu, Jianyong
    Guo, Dongjie
    Li, Fulun
    FRONTIERS IN MEDICINE, 2022, 9
  • [26] Nodular Regenerative Hyperplasia in HIV-positive patients : a case series and review of the literature
    Figueiredo, M.
    Nkuize, M.
    Mulkay, J. P.
    De Wit, S.
    Gomez, M.
    Serste, T.
    ACTA GASTRO-ENTEROLOGICA BELGICA, 2017, 80 (01): : 14 - 18
  • [27] Bullous pemphigoid associated with dipeptidyl peptidase IV inhibitors. A case report and review of literature
    Attaway, Amy
    Mersfelder, Tracey L.
    Vaishnav, Sakshi
    Baker, Joanne K.
    JOURNAL OF DERMATOLOGICAL CASE REPORTS, 2014, 8 (01): : 24 - 28
  • [28] Bullous scabies: A case report and review of the literature
    Arif Maan M.A.
    Arif Maan M.S.
    Amir Humza Sohail A.M.
    Arif M.
    BMC Research Notes, 8 (1)
  • [29] Role of physical factors in the pathogenesis of bullous pemphigoid: Case report series and a comprehensive review of the published work
    Danescu, Sorina
    Chiorean, Roxana
    Macovei, Victorina
    Sitaru, Cassian
    Baican, Adrian
    JOURNAL OF DERMATOLOGY, 2016, 43 (02) : 134 - 140
  • [30] Psoriasis vulgaris, bullous pemphigoid, metabolic syndrome - coincidence or common pathogenetic background? Case report
    Kalinska-Bienias, Agnieszka
    Lesniewska, Anna
    Bienias, Piotr
    Kowalewski, Cezary
    Wozniak, Katarzyna
    PRZEGLAD DERMATOLOGICZNY, 2014, 101 (04): : 294 - 298