Study of the Embryonic Toxicity of TiO2 and ZrO2 Nanoparticles

被引：13

作者：

Lyashenko, Elena Nikolaevna ^{[1
]}

Uzbekova, Leyla Djavadovna ^{[2
]}

Polovinkina, Valeri Vladimirovna ^{[1
]}

Dorofeeva, Anastasia Konstantinovna ^{[2
]}

Ibragimov, Said-Umar Sithalil-ugli ^{[1
]}

Tatamov, Arslan Ayavovich ^{[3
]}

Avkaeva, Albina Gamdullaevna ^{[3
]}

Mikhailova, Anastasia Alekseevna ^{[4
]}

Tuaeva, Inga Shamilevna ^{[5
]}

Esiev, Ruslan Kazbekovich ^{[6
]}

Mezentsev, Sergei Dmitrievich ^{[7
]}

Gubanova, Marina Alexandrovna ^{[8
]}

Bondarenko, Natalya Grigorevna ^{[9
]}

Maslova, Alina Yurievna ^{[4
,10
]}

机构：

[1] VI Vernadsky Crimean Fed Univ, SI Georgievsky Med Acad, Fac Pediat, Dept Obstet & Gynecol, Simferopol 295007, Russia

[2] Rostov State Med Univ, Fac Pediat, Rostov Na Donu 344009, Russia

[3] Dagestan State Med Univ, Fac Med, Makhachkala 367029, Russia

[4] Stavropol State Med Univ, Fac Med, Stavropol 355017, Russia

[5] North Ossetian State Med Acad, Fac Med & Prevent, Dept Hyg, Vladikavkaz 362019, Russia

[6] North Ossetian State Med Acad, Dept Dent, Vladikavkaz 362019, Russia

[7] Moscow State Univ Civil Engn, Dept Natl Res, Moscow 125009, Russia

[8] Armavir State Pedag Univ, Armavir 352901, Russia

[9] Pyatigorsk Branch North Caucasus Fed Univ, Dept Philosophy Hist Law, Pyatigorsk 357502, Russia

[10] SocMedica, Moscow 121205, Russia

来源：

MICROMACHINES | 2023年 / 14卷 / 02期

关键词：

titanium; zirconium; safety; nanoparticles; pregnancy; photon correlation spectroscopy; embryotoxicity; TITANIUM-DIOXIDE NANOPARTICLES; EXPOSURE; RATS; FIBROSIS; SILICA; OXIDE;

D O I：

10.3390/mi14020363

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Currently, the widespread use of TiO2 and ZrO2 nanoparticles (NPs) in various industries poses a risk in terms of their potential toxicity. A number of experimental studies provide evidence of the toxic effect of TiO2 and ZrO2 NPs on biological objects. In order to supplement the level of knowledge and assess the risks of toxicity and danger of TiO2 and ZrO2 NPs, we decided to conduct a comprehensive experiment to study the embryonic toxicity of TiO2 and ZrO2 NPs in pregnant rats. For the experiment, mongrel white rats during pregnancy received aqueous dispersions of powders of TiO2 and ZrO2 NPs at a dose of 100 mg/kg/day. To characterize the effect of TiO2 and ZrO2 NPs on females and the postnatal ontogenesis of offspring, a complex of physiological and biochemical research methods was used. The results of the experiment showed that TiO2 NPs as ZrO2 NPs (100 mg/kg per os) cause few shifts of similar orientation in the maternal body. Neither TiO2 NPs nor ZrO2 NPs have an embryonic and teratogenic effect on the offspring in utero, but both modify its postnatal development.

引用

页数：18

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