Triglyceride-glucose index is associated with poor sleep quality in apparently healthy subjects: A cross-sectional study

Objectives: We aimed to evaluate the association between the triglyceride glucose index (TyG index) and sleep quality and to establish a cut-off value for the TyG index based on the prevalence of subjects with insulin resistance (IR). Materials and methods:This cross-sectional study involved Brazilian health professionals (20-59 years). A total of 138 subjects answered the Pittsburgh Sleep Quality questionnaire to evaluate sleep quality. They were categorized into two groups: good sleep quality (global score <= 5 points) and poor sleep quality (global score >= 6 points). Also, we classified the subjects as having a high (>8.08 or >4.38) or low TyG index (<= 8.08 or <= 4.38). Results:The majority of the subjects (70%) with high TyG index values (>8.08 or >4.38) reported poor sleep quality (p <= 0.001). Those with poor sleep quality had a 1.44-fold higher prevalence of IR (TyG index >8.08 or >4.38) compared to those with good sleep quality, regardless of sex, total cholesterol, LDL/HDL ratio, insulin, complement C3, CRP, and adiponectin (p <= 0.001). Conclusion: Our data showed a positive and significant association between the TyG index and poor sleep quality. Thus, these findings support the association between poor sleep quality and IR. Arch Endocrinol Metab. 2023;67(1):73-91