The Long Telling Story of "Endothelial Progenitor Cells": Where Are We at Now?

被引：11

作者：

Vinci, Maria Cristina ^{[1
]}

Carulli, Ermes ^{[2
,3
]}

Rurali, Erica ^{[1
]}

Rinaldi, Raffaella ^{[1
]}

Damiano, Giulia ^{[1
]}

Raucci, Angela ^{[4
]}

Pompilio, Giulio ^{[1
,5
]}

Genovese, Stefano ^{[6
]}

机构：

[1] Ctr Cardiol Monzino IRCCS, Unit Vasc Biol & Regenerat Med, I-20138 Milan, Italy

[2] Univ Milan, Scuola Dottorato Med Traslaz, I-20100 Milan, Italy

[3] Univ Milan, Dipartimento Sci Clin & Comun, I-20100 Milan, Italy

[4] Ctr Cardiol Monzino IRCCS, Unit Expt Cardiooncol & Cardiovasc Aging, I-20138 Milan, Italy

[5] Univ Milan, Dipartimento Sci Biomed Chirurg & Odontoiatr, I-20100 Milan, Italy

[6] Ctr Cardiol Monzino IRCCS, Diabet Endocrine & Metab Dis Unit, I-20138 Milan, Italy

来源：

CELLS | 2023年 / 12卷 / 01期

关键词：

endothelial progenitor cells; CD34(+) hematopoietic stem progenitor cells; regenerative medicine; cardiovascular disease; angiogenesis; CIRCULATING CD34-POSITIVE CELLS; ISCHEMIC-HEART-DISEASE; MATTER AIR-POLLUTION; DYSFUNCTION BM CD34; BONE-MARROW; STEM-CELLS; HEMATOPOIETIC STEM; PERIPHERAL-BLOOD; CARDIOVASCULAR-DISEASE; REFRACTORY ANGINA;

D O I：

10.3390/cells12010112

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endothelial progenitor cells (EPCs): The name embodies years of research and clinical expectations, but where are we now? Do these cells really represent the El Dorado of regenerative medicine? Here, past and recent literature about this eclectic, still unknown and therefore fascinating cell population will be discussed. This review will take the reader through a temporal journey that, from the first discovery, will pass through years of research devoted to attempts at their definition and understanding their biology in health and disease, ending with the most recent evidence about their pathobiological role in cardiovascular disease and their recent applications in regenerative medicine.

引用

页数：22

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