The Psychedelic Future of Post-Traumatic Stress Disorder Treatment

被引:19
作者
Zaretsky, Tamar Glatman [1 ,2 ]
Jagodnik, Kathleen M. [2 ]
Barsic, Robert [1 ,2 ]
Antonio, Josimar Hernandez [2 ,3 ]
Bonanno, Philip A. [2 ]
Macleod, Carolyn [2 ]
Pierce, Charlotte [2 ,3 ]
Carney, Hunter [2 ]
Morrison, Morgan T. [1 ,2 ]
Saylor, Charles [2 ,3 ]
Danias, George [2 ,3 ]
Lepow, Lauren [2 ,3 ]
Yehuda, Rachel [1 ,2 ,3 ]
机构
[1] James J Peters Vet Affairs Med Ctr, New York, NY 10468 USA
[2] Icahn Sch Med Mt Sinai, Ctr Psychedel Psychotherapy & Trauma Res, New York, NY 10029 USA
[3] Icahn Sch Med Mt Sinai, New York, NY 10029 USA
关键词
3,4-methylenedioxymethamphetamine (MDMA); Ayahuasca; Ketamine; Lysergic Acid Diethylamide (LSD); Post-Traumatic Stress Disorder (PTSD); psilocybin; psychedelics; trauma; LYSERGIC-ACID DIETHYLAMIDE; MYSTICAL-TYPE EXPERIENCES; KETAMINE-ASSISTED PSYCHOTHERAPY; MAJOR DEPRESSIVE DISORDER; QUALITY-OF-LIFE; TREATMENT RESPONSE TRAJECTORIES; MEDIAL PREFRONTAL CORTEX; HEALTH-CARE UTILIZATION; DEFAULT MODE NETWORK; LONG-TERM;
D O I
10.2174/1570159X22666231027111147
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Post-traumatic stress disorder (PTSD) is a mental health condition that can occur following exposure to a traumatic experience. An estimated 12 million U.S. adults are presently affected by this disorder. Current treatments include psychological therapies (e.g., exposure-based interventions) and pharmacological treatments (e.g., selective serotonin reuptake inhibitors (SSRIs)). However, a significant proportion of patients receiving standard-of-care therapies for PTSD remain symptomatic, and new approaches for this and other trauma-related mental health conditions are greatly needed. Psychedelic compounds that alter cognition, perception, and mood are currently being examined for their efficacy in treating PTSD despite their current status as Drug Enforcement Administration (DEA)-scheduled substances. Initial clinical trials have demonstrated the potential value of psychedelic-assisted therapy to treat PTSD and other psychiatric disorders. In this comprehensive review, we summarize the state of the science of PTSD clinical care, including current treatments and their shortcomings. We review clinical studies of psychedelic interventions to treat PTSD, trauma-related disorders, and common comorbidities. The classic psychedelics psilocybin, lysergic acid diethylamide (LSD), and N,N-dimethyltryptamine (DMT) and DMT-containing ayahuasca, as well as the entactogen 3,4-methylenedioxymethamphetamine (MDMA) and the dissociative anesthetic ketamine, are reviewed. For each drug, we present the history of use, psychological and somatic effects, pharmacology, and safety profile. The rationale and proposed mechanisms for use in treating PTSD and trauma-related disorders are discussed. This review concludes with an in-depth consideration of future directions for the psychiatric applications of psychedelics to maximize therapeutic benefit and minimize risk in individuals and communities impacted by trauma-related conditions.
引用
收藏
页码:636 / 735
页数:100
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