Extracellular matrix remodeling in the tumor immunity

被引：37

作者：

Du, Wei ^{[1
]}

Xia, Xueming ^{[2
]}

Hu, Fan ^{[3
]}

Yu, Jiayun ^{[4
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Targeting Therapy & Immunol, Chengdu, Peoples R China

[2] Sichuan Univ, West China Hosp, Canc Ctr, Div Head & Neck Tumor Multimodal Treatment, Chengdu, Peoples R China

[3] West China Second Univ Hosp, West China Univ Hosp 2, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Peoples R China

[4] Sichuan Univ, West China Hosp, Canc Ctr, Dept Radiat Oncol, Chengdu, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 14卷

基金：

中国国家自然科学基金;

关键词：

extracellular matrix; tumor microenvironment; stiffness; cancer; immune cells; TENASCIN-C; T-CELLS; COLLAGEN; CANCER; EXPRESSION; HYALURONAN; MACROPHAGES; ACTIVATION; CD44; GROWTH;

D O I：

10.3389/fimmu.2023.1340634

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The extracellular matrix (ECM) is a significant constituent of tumors, fulfilling various essential functions such as providing mechanical support, influencing the microenvironment, and serving as a reservoir for signaling molecules. The abundance and degree of cross-linking of ECM components are critical determinants of tissue stiffness. In the process of tumorigenesis, the interaction between ECM and immune cells within the tumor microenvironment (TME) frequently leads to ECM stiffness, thereby disrupting normal mechanotransduction and promoting malignant progression. Therefore, acquiring a thorough comprehension of the dysregulation of ECM within the TME would significantly aid in the identification of potential therapeutic targets for cancer treatment. In this regard, we have compiled a comprehensive summary encompassing the following aspects: (1) the principal components of ECM and their roles in malignant conditions; (2) the intricate interaction between ECM and immune cells within the TME; and (3) the pivotal regulators governing the onco-immune response in ECM.

引用

页数：16

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