Endogenous CO imaging in bacterial pneumonia with a NIR fluorescent probe

被引:24
|
作者
Zhu, Beitong [1 ]
Xing, Xuejian [2 ]
Kim, Jungryun [3 ]
Rha, Hyeonji [3 ]
Liu, Chun [4 ]
Zhang, Qiang [4 ]
Zeng, Lintao [1 ]
Lan, Minhuan [2 ]
Kim, Jong Seung [3 ]
机构
[1] Guangxi Univ, Sch Light Ind & Food Engn, Nanning 530004, Guangxi, Peoples R China
[2] Cent South Univ, Coll Chem & Chem Engn, Key Lab Hunan Prov Water Environm & Agr Prod Safet, Changsha 410083, Hunan, Peoples R China
[3] Korea Univ, Dept Chem, Seoul 02841, South Korea
[4] Cent South Univ, Xiangya Hosp 3, Dept Respirol & Crit Care Med, Changsha 410083, Hunan, Peoples R China
基金
新加坡国家研究基金会; 中国国家自然科学基金;
关键词
Near-infrared; Fluorescent probe; Photoacoustic imaging; Bacterial pneumonia; BODIPY; Carbon monoxide; TURN-ON PROBE; CHEST-X-RAY; CARBON-MONOXIDE; LIVING CELLS; IN-VIVO; COMPUTED-TOMOGRAPHY; SELECTIVE DETECTION; FLUOROGENIC PROBE; RATIONAL DESIGN; RELEASE;
D O I
10.1016/j.biomaterials.2023.122419
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Bacterial pneumonia is a serious respiratory illness that poses a great threat to human life. Rapid and precise diagnosis of bacterial pneumonia is crucial for symptomatic clinical treatment. Endogenous carbon monoxide (CO) is regarded as a significant indicator of bacterial pneumonia; herein, we developed a near-infrared (NIR) probe for fluorescence and photoacoustic (PA) dual-mode imaging of endogenous CO in bacterial pneumonia. NO2-BODIPY could rapidly and specifically react with CO to produce strong NIR fluorescence as well as ratiometric PA signals. NO2-BODIPY has outstanding features including fast response, fluorescence/PA dual mode signals, good specificity, and a low limit of detection (LOD = 20.3 nM), which enables it to image endogenous CO in cells and bacterial pneumonia mice with high sensitivity and high contrast ratio. In particular, NO2-BODIPY has two-photon excited (1340 nm, sigma(1) = 1671 GM) NIR fluorescence and has been utilized to image endogenous CO in bacterial pneumonia mice with deep tissue penetration. NO2-BODIPY has been demonstrated a good capability of fluorescence/PA dual-mode imaging of CO in bacterial pneumonia mice, providing a precise manner to diagnose bacterial pneumonia.
引用
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页数:12
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