Combination of Immunotherapy and Radiation Therapy in Gastrointestinal Cancers: An Appraisal of the Current Literature and Ongoing Research

被引：5

作者：

Kumar, Ritesh ^{[1
]}

Kim, Jongmyung ^{[1
]}

Deek, Matthew P. P. ^{[1
]}

Eskander, Mariam F. F. ^{[2
]}

Gulhati, Prateek ^{[3
]}

In, Haejin ^{[2
]}

Kennedy, Timothy ^{[2
]}

Shah, Mihir M. M. ^{[4
]}

Grandhi, Miral S. S. ^{[2
]}

Berim, Lyudmyla ^{[3
]}

Spencer, Kristen R. R. ^{[5
]}

Langan, Russell C. C. ^{[2
]}

Hochster, Howard S. S. ^{[3
]}

Boland, Patrick M. M. ^{[3
]}

Jabbour, Salma K. K. ^{[1
]}

机构：

[1] Rutgers Canc Inst New Jersey, Robert Wood Johnson Med Sch, Dept Radiat Oncol, New Brunswick, NJ 08903 USA

[2] Rutgers Canc Inst New Jersey, Robert Wood Johnson Med Sch, Dept Surg Oncol, New Brunswick, NJ 08903 USA

[3] Rutgers Canc Inst New Jersey, Robert Wood Johnson Med Sch, Dept Med Oncol, New Brunswick, NJ 08903 USA

[4] Emory Univ, Sch Med, Dept Surg, Div Surg Oncol, Atlanta, GA 30322 USA

[5] NYU Grossman Sch Med, Perlmutter Canc Ctr NYU Langone Hlth, Dept Med, New York, NY 10016 USA

来源：

CURRENT ONCOLOGY | 2023年 / 30卷 / 07期

关键词：

immunotherapy; radiation; PD L1; immune checkpoint inhibitors; UNRESECTABLE HEPATOCELLULAR-CARCINOMA; STEREOTACTIC BODY RADIOTHERAPY; CHEMORADIATION THERAPY; ESOPHAGEAL; NIVOLUMAB; EFFICACY; TRIAL; CHOLANGIOCARCINOMA; ANTI-PD-1; SBRT;

D O I：

10.3390/curroncol30070473

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oncological outcomes are improving in gastrointestinal cancer with advancements in systemic therapies, and there is notable potential in combining immunotherapy and radiation therapy (RT) to allow for further improvements. Various preclinical and early phase II studies have shown promising synergy with immunotherapy and RT in gastrointestinal cancer. A few recent phase III studies have shown improved survival with the addition of immunotherapy to standard treatment for gastrointestinal cancer. The timing, duration, sequencing, and integration with other anti-cancer treatments are still areas of ongoing research. We have reviewed the published and ongoing studies of the combinations of immunotherapy and RT in gastrointestinal cancers.

引用

页码：6432 / 6446

页数：15

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