"Double-Edged Sword" Effect of Reactive Oxygen Species (ROS) in Tumor Development and Carcinogenesis

被引：23

作者：

Zhao, Wenqi ^{[1
,2
]}

Zhuang, Peizhen ^{[1
]}

Chen, Yixi ^{[1
]}

Wu, Yi ^{[1
]}

Zhong, Mintao ^{[2
]}

Lun, Yongzhi ^{[1
,3
]}

机构：

[1] Putian Univ, Fujian Prov Univ, Sch Pharm & Med Technol, Key Lab Med Microecol, Putian, Peoples R China

[2] Dalian Med Univ, Dept Microbiol, Dalian, Peoples R China

[3] Putian Univ, Fujian Prov Univ, Sch Pharm & Med Technol, Key Lab Med Microecol, Putian 351100, Peoples R China

来源：

PHYSIOLOGICAL RESEARCH | 2023年 / 72卷 / 03期

关键词：

Reactive Oxygen Species (ROS); Angiogenesis; Metastasis; Apoptosis; Oncotherapy; CANCER-CELL APOPTOSIS; OXIDATIVE STRESS; DOWN-REGULATION; ARSENIC TRIOXIDE; LUNG-CANCER; BREAST-CANCER; FREE-RADICALS; STEM-CELLS; IN-VITRO; AUTOPHAGY;

D O I：

10.33549/physiolres.935007

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Reactive oxygen species (ROS) are small reactive molecules produced by cellular metabolism and regulate various physiological and pathological functions. Many studies have shown that ROS plays an essential role in the proliferation and inhibition of tumor cells. Different concentrations of ROS can have a "double-edged sword" effect on the occurrence and development of tumors. A certain concentration of ROS can activate growth-promoting signals, enhance the proliferation and invasion of tumor cells, and cause damage to biomacromolecules such as proteins and nucleic acids. However, ROS can enhance application.

引用

页码：301 / 317

页数：17

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