4-Membered Ring Carbocations: A Positive Development in the Synthesis of 3,3-Disubstituted Oxetanes and Azetidines

被引：4
|
作者：
Rojas, Juan J. [1 ]
Bull, James A. [1 ]
机构：
[1] Imperial Coll London, Dept Chem, London W12 OBZ, England
来源：
CHIMIA | 2023年 / 77卷 / 04期
关键词：
Azetidines; Bioisosteres; Carbocations; Chemical space; Oxetanes; FRIEDEL-CRAFTS ALKYLATION;
D O I：
10.2533/chimia.2023.192
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
4-Membered heterocycles are low molecular weight polar scaffolds with intriguing potential for drug discovery. Despite their unquestionable value, methods to access such heterocycles remain scant. Here, we de-scribe the generation of oxetane-and azetidine-benzylic carbocations as a general strategy to access valuable 3,3-disubstituted derivatives.
引用
收藏
页码：192 / 195
页数：4
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