Direct synthesis of a-Ketothioamides from in situ generated a-Keto sulfines and amines via the thioamide bond construction

被引：9
作者：
Dong, Jun [1 ]
Sheng, Chengcai [1 ]
Chen, Youwei [1 ]
Ni, Chunjie [1 ]
Wang, Yanqing [1 ]
机构：
[1] Yancheng Teachers Univ, Sch Chem & Environm Engn, Yancheng 224007, Peoples R China
来源：
TETRAHEDRON LETTERS | 2023年 / 115卷
基金：
中国国家自然科学基金;
关键词：
a-Keto sulfines; Thioamide bond; a-Ketothioamides; ALPHA-KETOTHIOAMIDES; ELEMENTAL SULFUR; THIOFORMANILIDES; DERIVATIVES; CYCLIZATION; SULFOXIDES;
D O I：
10.1016/j.tetlet.2022.154317
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have developed a practical, general protocol from readily available phenacyl sulfoxides bearing tetra-zoles with amines to access a broad scope of a-ketothioamides under mild conditions. The reaction has good substrate applicability, and provides an efficient, green and convenient method for the preparation of a-ketothioamide compounds under metal-, oxidant-and catalyst-free conditions.(c) 2022 Elsevier Ltd. All rights reserved.
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页数：4
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