Polymeric Nanocomposite Hydrogel Scaffolds in Craniofacial Bone Regeneration: A Comprehensive Review

被引:17
作者
Bashir, Maha H. [1 ]
Korany, Nahed S. [1 ]
Farag, Dina B. E. [1 ]
Abbass, Marwa M. S. [1 ,2 ]
Ezzat, Bassant A. [1 ]
Hegazy, Radwa H. [1 ]
Doerfer, Christof E. [3 ]
El-Sayed, Karim M. Fawzy M. [2 ,3 ,4 ]
机构
[1] Cairo Univ, Fac Dent, Oral Biol Dept, Cairo 11553, Egypt
[2] Cairo Univ, Fac Dent, Stem Cells & Tissue Engn Res Grp, Cairo 11553, Egypt
[3] Univ Kiel, Sch Dent Med, Clin Conservat Dent & Periodontol, D-24105 Kiel, Germany
[4] Cairo Univ, Fac Dent, Oral Med & Periodontol Dept, Cairo 11553, Egypt
基金
英国科研创新办公室;
关键词
nanohydrogels; craniofacial defects; maxillofacial defects; tissue engineering; COLLOIDAL GELATIN GELS; CELL-DERIVED FACTOR-1-ALPHA; NERVE GROWTH-FACTOR; DRUG-DELIVERY; HYALURONIC-ACID; IN-VITRO; MORPHOGENETIC PROTEIN-2; INJECTABLE HYDROGEL; CONTROLLED-RELEASE; DOPED HYDROXYAPATITE;
D O I
10.3390/biom13020205
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nanocomposite biomaterials combine a biopolymeric matrix structure with nanoscale fillers. These bioactive and easily resorbable nanocomposites have been broadly divided into three groups, namely natural, synthetic or composite, based on the polymeric origin. Preparing such nanocomposite structures in the form of hydrogels can create a three-dimensional natural hydrophilic atmosphere pivotal for cell survival and new tissue formation. Thus, hydrogel-based cell distribution and drug administration have evolved as possible options for bone tissue engineering and regeneration. In this context, nanogels or nanohydrogels, created by cross-linking three-dimensional polymer networks, either physically or chemically, with high biocompatibility and mechanical properties were introduced as promising drug delivery systems. The present review highlights the potential of hydrogels and nanopolymers in the field of craniofacial tissue engineering and bone regeneration.
引用
收藏
页数:31
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