Nano-Calcium Carbonate Affect the Respiratory and Function Through Inducing Oxidative Stress A Cross-sectional Study Among Occupational Exposure of Workers and a Further Research for Underlying Mechanisms

被引：0

作者：

Lyu, Yi ^{[1
,2
]}

Zhang, Qian ^{[1
]}

Liu, Yan ^{[1
]}

Zhang, Wen-Ping ^{[1
]}

Tian, Feng-Jie ^{[1
]}

Zhang, Hui-Fang ^{[1
]}

Hu, Bo-Hua ^{[1
]}

Feng, Juan ^{[1
]}

Qian, Yi ^{[1
]}

Jiang, Yong ^{[1
]}

Zhang, Pan-Hong ^{[1
]}

Ma, Ning ^{[1
]}

Tang, Shi-Chuan ^{[4
]}

Zheng, Jin-Ping ^{[1
,3
]}

Qiu, Yu-Lan ^{[1
]}

机构：

[1] Shanxi Med Univ, Sch Publ Hlth, Dept Hlth Toxicol, 56 Xinjian South Rd, Taiyuan 030001, Peoples R China

[2] Shanxi Med Univ, Sch Preclin Med, Dept Biochem & Mol Biol, Taiyuan, Peoples R China

[3] Changzhi Med Coll, Dept Publ Hlth & Prevent Med, Changzhi, Peoples R China

[4] Beijing Acad Sci & Technol, Inst Urban Safety & Environm Sci, Beijing, Peoples R China

来源：

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 2023年 / 65卷 / 02期

关键词：

biodistribution; cross-sectional study; nano-calcium carbonate; occupational exposure; oxidative stress; respiratory; ENGINEERED NANOPARTICLES; AMBIENT ULTRAFINE; OXIDE; BIODISTRIBUTION; NANOTOXICOLOGY; NANOMATERIALS; CYTOTOXICITY; TOXICITY;

D O I：

10.1097/JOM.0000000000002713

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

ObjectiveThe aim of the study is to investigate whether nano-calcium carbonate (nano-CaCO3) occupational exposure could induce adverse health effects in workers.MethodsA cross-sectional study was conducted in a nano-CaCO3 manufacturing plant in China. Then, we have studied the dynamic distribution of nano-CaCO3 in nude mice and examined the oxidative damage biomarkers of subchronic administrated nano-CaCO3 on Sprague-Dawley rats.ResultsThe forced vital capacity (%) and the ratio of FEV1 to FVC is the rate of one second of workers were significantly decreased than unexposed individuals. Dynamic imaging in mice of fluorescence labeled nano-CaCO3 showed relatively high uptake and slow washout in lung. Similar to population data, the decline in serum glutathione level and elevation in serum MDA were observed in nano-CaCO3-infected Sprague-Dawley rats.ConclusionsWe found that nano-CaCO3 exposure may result in the poor pulmonary function in workers and lead to the changes of oxidative stress indexes.

引用

页码：184 / 191

页数：8

共 1 条

[1] Pulmonary hypofunction due to calcium carbonate nanomaterial exposure in occupational workers: a cross-sectional study
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Yang, Zhanhong
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Yang, Aichu
Chen, Jiabing
Wu, Banghua
Xu, Huaming
Meng, Dezhi
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Yang, Xingfen
Li, Laiyu
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Huang, Hanlin
Huang, Zhenlie
NANOTOXICOLOGY, 2018, 12 (06) : 571 - 585

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