Discovery of Novel Cysteine Protease Inhibitors for the Treatment of Coronavirus (COVID-19)

被引：1

作者：

De, Surya K. ^{[1
,2
]}

机构：

[1] Conju Probe, Dept Chem, San Diego, CA 92121 USA

[2] Bharath Univ, Dept Chem, Chennai 600126, Tamil Nadu, India

来源：

CURRENT MEDICINAL CHEMISTRY | 2024年 / 31卷 / 09期

关键词：

Cysteine protease inhibitors; COVID-19; cysteine proteases; 3C-like protease; paxlovid; molnupiravir; STRUCTURE-BASED DESIGN;

D O I：

10.2174/0929867330666230519163305

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The application describes compounds, such as compounds of general Formula, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and synthetic methods of various compounds with warheads are included. The compounds are inhibitors of proteases, such as the 3C, CL- or 3CL-like protease.

引用

页码：1165 / 1169

页数：5

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