Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1

被引：9
作者：
Fang, Huan [1 ,2 ]
Ren, Wenlong [1 ,3 ]
Cui, Qiuxia [1 ,4 ,5 ]
Liang, Huichun [1 ]
Yang, Chuanyu [1 ]
Liu, Wenjing [1 ]
Wang, Xinye [1 ]
Liu, Xue [6 ]
Shi, Yujie [7 ]
Feng, Jing [6 ,8 ,9 ]
Chen, Ceshi [1 ,10 ,11 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Zool, Kunming, Yunnan, Peoples R China
[2] Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming, Yunnan, Peoples R China
[3] Univ Sci & Technol China, Sch Life Sci, Hefei, Peoples R China
[4] Guangdong Med Univ, Affiliated Hosp, Zhanjiang, Guangdong, Peoples R China
[5] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp & Shenzhen Hosp, Natl Clin Res Ctr Canc, Dept Breast Surg Oncol,Natl Canc Ctr, Shenzhen, Guangdong, Peoples R China
[6] Shanghai Univ Med & Hlth Sci, Affiliated Peoples Hosp 6, South Campus, Shanghai 201499, Peoples R China
[7] Zhengzhou Univ, Henan Prov Peoples Hosp, Dept Pathol, Zhengzhou, Peoples R China
[8] Chinese Univ Hong Kong, Affiliated Hosp 2, Shenzhen, Peoples R China
[9] Southern Med Univ, Sch Lab Med & Biotechnol, Guangzhou, Guangdong, Peoples R China
[10] Kunming Med Univ, Acad Biomed Engn, Kunming, Peoples R China
[11] Kunming Med Univ, Affiliated Hosp 3, Kunming, Peoples R China
来源：
ELIFE | 2023年 / 12卷
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
ITGB4; TNFAIP2; IQGAP1; RAC1; drug resistance; triple-negative breast cancer; Human; RAC; ACTIVATION; METASTASIS; CARCINOMA; PROTEINS; TNFAIP2; IQGAP1; GENE; AKT;
D O I：
10.7554/eLife.88483
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Anti-tumor drug resistance is a challenge for human triple-negative breast cancer (TNBC) treatment. Our previous work demonstrated that TNFAIP2 activates RAC1 to promote TNBC cell proliferation and migration. However, the mechanism by which TNFAIP2 activates RAC1 is unknown. In this study, we found that TNFAIP2 interacts with IQGAP1 and Integrin beta 4. Integrin beta 4 activates RAC1 through TNFAIP2 and IQGAP1 and confers DNA damage-related drug resistance in TNBC. These results indicate that the Integrin beta 4/TNFAIP2/IQGAP1/RAC1 axis provides potential therapeutic targets to overcome DNA damage-related drug resistance in TNBC.
引用
收藏
页数：21
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