Low-Intensity Pulsed Ultrasound Maintains Bone Mass After Withdrawal of Human Parathyroid Hormone in Ovariectomized Mice

被引：1
作者：
Kojima, Yoshitsugu [1 ,2 ,5 ]
Watanabe, Takayuki [1 ,2 ]
Mizuki, Fumitaka [2 ]
Izumo, Nobuo [3 ,4 ]
Nishimura, Yoshihiro [2 ]
机构：
[1] Yokohama Univ Pharm, Clin Pharmacol Res Lab, Yokohama, Kanagawa, Japan
[2] Nippon Sigmax Co Ltd, Planning & Prod Dev Div, Shinjuku Ku, Tokyo, Japan
[3] Yokohama Univ Pharm, Gen Hlth Med Res Ctr, Yokohama, Kanagawa, Japan
[4] Yokohama Univ Pharm, Lab Pharmacotherapy, Yokohama, Kanagawa, Japan
[5] Yokohama Univ Pharm, Clin Pharmacol Res Lab, 601 Matanocho Totsukaku, Yokohama, Kanagawa 2450066, Japan
来源：
JOURNAL OF ULTRASOUND IN MEDICINE | 2024年 / 43卷 / 02期
关键词：
low-intensity pulsed ultrasound (LIPUS); osteoporosis; teriparatide; withdrawal; POSTMENOPAUSAL WOMEN; OSTEOGENIC DIFFERENTIATION; MECHANICAL-STRESS; OSTEOPOROSIS; FRACTURE; TERIPARATIDE; DENOSUMAB; THERAPY; RAT; OSTEOPROTEGERIN;
D O I：
10.1002/jum.16371
中图分类号：
O42 [声学];
学科分类号：
070206 ; 082403 ;
摘要：
The intermittent injection of teriparatide, a recombinant fragment of human parathyroid hormone (PTH 1-34), activates anabolic activity on bone turnover. However, the PTH administration period is limited to 2 years. Thus, sequential therapy after discontinuation of PTH is required. Low-intensity pulsed ultrasound (LIPUS) has been widely used for bone fracture healing. In this study, we examined the effects of LIPUS on bone mass after PTH withdrawal in ovariectomized (OVX) model mice. The LIPUS-non-irradiated femoral trabecular bone mineral density (BMD) in the treated after PTH withdrawal was significantly decreased. Meanwhile, the femoral BMD in the OVX + PTH-LIPUS group was remarkably higher than that of the OVX group. Additionally, mRNA expression of Runx2, Osterix, Col1a1, and ALP increased significantly following LIPUS irradiation after PTH withdrawal. These results suggest that LIPUS protected against femoral trabecular BMD loss and up-regulated the osteogenic factors following PTH withdrawal in OVX mice.
引用
收藏
页码：385 / 395
页数：11
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