ER-mitochondria contact sites in mitochondrial DNA dynamics, maintenance, and distribution

被引：4

作者：

Ilamathi, Hema Saranya ^{[1
,2
,3
,4
,5
]}

Germain, Marc ^{[1
,2
,3
,4
]}

机构：

[1] Univ Quebec Trois Rivieres, Grp Rech Signalisat Cellulaire, Trois Rivieres, PQ, Canada

[2] Univ Quebec Trois Rivieres, Dept Biol Med, Trois Rivieres, PQ, Canada

[3] Univ Quebec Montreal, Fdn Courtois, Ctr Excellence Rech Malad Orphelines, Montreal, PQ, Canada

[4] Reseau Intersectoriel Rech Sante Univ Quebec RISUQ, Montreal, PQ, Canada

[5] Karolinska Inst, Dept Lab Med, Div Biomol & Cellular Med, Huddinge, Sweden

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2024年 / 166卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

mtDNA-nucleoid; ER sheets; Mitochondria; ERMCS; NUCLEOIDS; FISSION; ACTIN;

D O I：

10.1016/j.biocel.2023.106492

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria are central cellular metabolic hubs. Their function requires proteins encoded by nuclear DNA, but also mitochondrial DNA (mtDNA) whose maintenance is essential for the proper function of the organelle. Defective mtDNA maintenance and distribution are associated with mitochondrial diseases. mtDNA is organized into nucleo-protein complexes called nucleoids that dynamically move along the mitochondrial network and interact with each other. mtDNA replication and nucleoid distribution is an active process regulated by the complex interplay of mitochondrial dynamics, endoplasmic reticulum (ER)-mitochondria contact sites, and cytoskeletal networks. For example, defects in mitochondrial fusion and fission or ER-mitochondria contact sites affect nucleoid maintenance and distribution. In this review, we discuss the process of nucleoid dynamics and the factors regulating nucleoid maintenance and distribution.

引用

页数：4

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