Targeting stress granules in neurodegenerative diseases: A focus on biological function and dynamics disorders

被引：5
作者：
Fang, Minglv [1 ]
Liu, Ying [1 ]
Huang, Cheng [1 ]
Fan, Shengjie [1 ,2 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
来源：
BIOFACTORS | 2024年 / 50卷 / 03期
关键词：
Alzheimer's disease; amyotrophic lateral sclerosis; neurodegeneration; stress granules; AMYOTROPHIC-LATERAL-SCLEROSIS; PHASE-SEPARATION; PROTEIN INTERACTIONS; FUS; APOPTOSIS; TRANSLATION; AGGREGATION; INACTIVATION; CONDENSATION; TRANSITION;
D O I：
10.1002/biof.2017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Stress granules (SGs) are membraneless organelles formed by eukaryotic cells in response to stress to promote cell survival through their pleiotropic cytoprotective effects. SGs recruit a variety of components to enhance their physiological function, and play a critical role in the propagation of pathological proteins, a key factor in neurodegeneration. Recent advances indicate that SG dynamic disorders exacerbate neuronal susceptibility to stress in neurodegenerative diseases (NDs) including Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Huntington's disease (HD) and Parkinson's disease (PD). Here, we outline the biological functions of SGs, highlight SG dynamic disorders in NDs, and emphasize therapeutic approaches for enhancing SG dynamics to provide new insights into ND intervention.
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页码：422 / 438
页数：17
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