Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study

被引：4

作者：

Rodriguez-Martin, Inmaculada ^{[1
]}

Villanueva-Martin, Gonzalo ^{[1
]}

Guillen-Del-Castillo, Alfredo ^{[2
]}

Ortego-Centeno, Norberto ^{[3
,4
]}

Callejas, Jose L. ^{[3
]}

Simeon-Aznar, Carmen P. ^{[2
]}

Martin, Javier ^{[1
]}

Acosta-Herrera, Marialbert ^{[1
,3
]}

机构：

[1] Inst Parasitol & Biomed Lopez Neyra, CSIC, Granada 18016, Spain

[2] Hosp Univ Vall dHebron, Dept Internal Med, Barcelona 08035, Spain

[3] Hosp Clin San Cecilio, Syst Autoimmune Dis Unit, Inst Invest Biosanit Ibs GRANADA, Granada 18012, Spain

[4] Univ Granada, Dept Med, Granada 18016, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 21期

关键词：

systemic sclerosis; telomere length; mendelian randomization; MULTIPLE SUSCEPTIBILITY LOCI; ASSOCIATION; IDENTIFICATION; DYSFUNCTION; SCLERODERMA; PHENOTYPE;

D O I：

10.3390/ijms242115589

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although previous studies have suggested a relationship between telomere shortening and systemic sclerosis (SSc), the association between these two traits remains poorly understood. The objective of this study was to assess the causal relationship between telomere length in leukocytes (LTL) and SSc using the two-sample Mendelian randomization approach, with the genome-wide association study data for both LTL and SSc. The results of inverse-variance weighted regression (OR = 0.716 [95% CI 0.528-0.970], p = 0.031) and the Mendelian randomization pleiotropy residual sum and outlier method (OR = 0.716 [95% CI 0.563-0.911], p = 0.035) indicate an association between telomere length and SSc. Specifically, longer genetically predicted LTL is associated with a reduced risk of SSc. Sensitivity tests highlight the significant roles of the variants rs10936599 and rs2736100 annotated to the TERC and TERT genes, respectively. Our findings suggest an influence of telomere length in leukocytes on the development of SSc.

引用

页数：8

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