Preparation and evaluation of transdermal hydrogel of chitosan coated nanocurcumin for enhanced stability and skin permeability

被引:5
作者
Faris, Tarek M. [1 ]
Ahmad, Adel M. [2 ,3 ]
Mohammed, Hamdoon A. [3 ,4 ]
Alamoudi, Jawaher Abdullah [1 ]
Alsunbul, Maha [1 ]
Alrashidi, Amal [1 ]
Abdullah, Omeima [5 ]
Altwaijry, Najla [1 ,3 ]
Hassan, Abeer S. [6 ]
机构
[1] Princess Nourah Bint Abdulrahman Univ, Coll Pharm, Dept Pharmaceut Sci, Riyadh 11671, Saudi Arabia
[2] South Valley Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Qena 83523, Egypt
[3] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Qasim 51452, Saudi Arabia
[4] Al Azhar Univ, Fac Pharm, Dept Pharmacognosy & Med Plants, Cairo 11371, Egypt
[5] Umm Al Qura Univ, Coll Pharm, Dept Pharmaceut Chem, Mecca 24382, Saudi Arabia
[6] South Valley Univ, Fac Pharm, Dept Pharmaceut, Qena 83523, Egypt
关键词
Curcumin; Nanotechnology; Hydrogel; Skin permeability; HPLC; Chitosan Coated Nanocurcumin; IN-VITRO; DELIVERY; NANOPARTICLES; FORMULATION; CURCUMIN; DRUG; GEL; NANOCRYSTALS; VIVO; NANOSUSPENSION;
D O I
10.1016/j.arabjc.2023.105302
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Curcumin (CR) is a natural product that has great interest in biopharmaceutical applications. It has sev-eral biological effects that antagonizes inflammation, oxidative stress, and cancer. On the other hand, low aqueous solubility, stability, and dissolution rate are the main challenges to using curcumin. In the present investigation, curcumin was formulated as a nanosystem known as nanocurcumin using a combina-tion of polyvinyl pyrrolidone (PVP) with different polymers as stabilizing agents. The nanocurcumin formulations were prepared and evaluated by measuring the particle size, surface charge, drug content, and stability. The selected nanocurcumin formulation prepared using PVPK30-Poloxamer 188 demonstrated a significantly smaller particle size (272.1 +/- 15.32 nm) and a higher settlement volume ration as compared with other formulations. Also, the selected formulation showed higher solubility and disso-lution rates as compared with other stabilizer combinations. Chitosan was added to the selected nanocur-cumin formulation as a coating polymer to enhance short-term storage colloidal stability. The result of stability proved that chitosan (0.05%)-coated nanocurcumin dispersion showed good stability during storage as compared with non-coated nanocurcumin. Non-coated nanocurcumin and chitosan-coated curcumin were loaded into the Carbopol934 hydrogel matrix to investigate the effect on curcumin permeability across the skin. The results revealed that nanocurcumin hydrogel formulations showed a significantly higher amount of curcumin permeated across the skin.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
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页数:12
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