Changes of inflammation in patients with psoriatic arthritis after high intensity interval training assessed by ultrasound and MRI, a randomized controlled trial

被引：5

作者：

Thomsen, Ruth Stoklund ^{[1
,2
,3
]}

Nilsen, Tom Ivar Lund ^{[4
,5
]}

Haugeberg, Glenn ^{[1
,6
]}

Sitter, Beathe ^{[2
]}

Kavanaugh, Arthur ^{[7
]}

Pedersen, Susanne Juhl ^{[8
]}

Hoff, Mari ^{[1
,3
]}

机构：

[1] Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci, NTNU, POB 8905, N-7491 Trondheim, Norway

[2] Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Circulat & Med Imaging, NTNU, Trondheim, Norway

[3] Univ Trondheim Hosp, St Olavs Hosp, Dept Rheumatol, Trondheim, Norway

[4] Norwegian Univ Sci & Technol, Dept Publ Hlth & Nursing, NTNU, Trondheim, Norway

[5] Univ Trondheim Hosp, St Olavs Hosp, Dept Anaesthesia & Intens Care, N-7006 Trondheim, Norway

[6] Hosp Southern Norway Trust, Div Rheumatol, Dept Internal Med, Kristiansand, Norway

[7] Univ Calif San Diego, Sch Med, Div Rheumatol Allergy & Immunol, La Jolla, CA USA

[8] Rigshosp, Copenhagen Ctr Arthrit Res COPECARE, Ctr Rheumatol & Spine Dis, Glostrup, Denmark

来源：

BMC MUSCULOSKELETAL DISORDERS | 2023年 / 24卷 / 01期

关键词：

Psoriatic arthritis; Exercise; Inflammation; Magnetic Resonance Imaging; Ultrasonography; SPONDYLOARTHRITIS RESEARCH CONSORTIUM; RESONANCE-IMAGING INDEX; DISEASE-ACTIVITY; ENTHESITIS; EXERCISE; IMPACT; SCORE;

D O I：

10.1186/s12891-023-06871-3

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

BackgroundIn psoriatic arthritis (PsA) there is a theoretical risk of increased disease activity related to strenuous physical activity, including exercise. We evaluated the effect of high intensity interval training (HIIT) on objective measures of inflammation in PsA assessed by ultrasound (US) of peripheral joints and entheses, and by bone marrow edema (BME) on MRI of the sacroiliac joints (SIJ) and spine.MethodsWe randomly assigned 67 PsA patients to an intervention group that performed structured HIIT for 11 weeks, or to a control group instructed not to change their physical exercise habits. Outcome measures included US evaluation of the total cohort and MRI in a subgroup of 41; both assessed at 3 months. We calculated the proportions with an increased US B-mode and power-doppler (PD) signal of joints and entheses and Spondyloarthritis-Research-Consortium-of-Canada (SPARCC)-BME score of the SIJ and spine for both groups.ResultsProportions with an increased US B-mode score of the joints were 32% and 28% in HIIT and control groups, respectively. Corresponding proportions of PD scores of the joints were 7% and 10% and PD scores of entheses were 32% and 31%.The proportions with increased MRI BME of the SIJ were 6% in the HIIT group and 10% in the control group. Corresponding proportions were 6% and 5% for the MRI BME of the spine.ResultsProportions with an increased US B-mode score of the joints were 32% and 28% in HIIT and control groups, respectively. Corresponding proportions of PD scores of the joints were 7% and 10% and PD scores of entheses were 32% and 31%.The proportions with increased MRI BME of the SIJ were 6% in the HIIT group and 10% in the control group. Corresponding proportions were 6% and 5% for the MRI BME of the spine.ConclusionIn PsA patients with a low to moderate disease activity, there was no clear evidence of objectively measured increased inflammation after HIIT, as evaluated by US and MRI.Trial registrationClinicalTrials.gov NCT02995460 (16/12/2016).

引用

页数：9

共 49 条

[1] Imaging in the diagnosis and management of peripheral psoriatic arthritis [J].