Navigating the Complexities of Intraventricular Hemorrhage in Preterm Infants: An Updated Review

被引:4
|
作者
Reddy, Pulliahgaru Apeksha [1 ]
Sreenivasulu, Himabindu [2 ]
Shokrolahi, Mohammad [3 ]
Muppalla, Sudheer Kumar [4 ]
Abdilov, Nurlan [3 ]
Ramar, Rajasekar [5 ]
Nagaraj, Raghu Halappa [6 ]
Vuppalapati, Sravya [4 ]
机构
[1] PES Inst Med Sci & Res, Pediat Med, Kuppam, India
[2] PES Inst Med Sci & Res, Gen Med, Kuppam, India
[3] Univ Debrecen, Internal Med, Debrecen, Hungary
[4] PES Inst Med Sci & Res, Pediat, Kuppam, India
[5] Rajah Muthiah Med Coll & Hosp, Internal Med, Chidambaram, India
[6] Avalon Univ, Surg, Sch Med, Willemstad, Curacao
关键词
intraventricular hemorrhage; microcirculation; cognitive impairment; phenobarbital; drift; neurosurgery; neurological; germinal matrix; neonatal; preterm infants; POSTHEMORRHAGIC HYDROCEPHALUS; PREMATURE-INFANTS; GERMINAL MATRIX; MANAGEMENT; PREVENTION; BIRTH; TERM;
D O I
10.7759/cureus.38985
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Intraventricular hemorrhage (IVH) is a type of bleeding that occurs in the ventricular cavity of the brain. In this comprehensive study, we provide a summary of the pathogenesis, diagnosis, and treatment of intraventricular hemorrhage in premature infants. Preterm babies are at high risk of developing IVH because their germinal matrix is not fully developed, making their blood vessels more prone to rupture. However, that is not necessarily the case in all preterm babies as the inherent structure of the germinal matrix makes it more susceptible to hemorrhage. Incidences of IVH are discussed based on recent data which states that around 12,000 premature infants in the United States experience IVH each year. Although grades I and II make up the majority of IVH cases and are frequently asymptomatic, IVH remains a significant issue for premature infants in neonatal intensive care facilities worldwide. Grades I and II have been linked to mutations in the type IV procollagen gene, COL4A1, as well as prothrombin G20210A and factor V Leiden mutations. Intraventricular hemorrhage can be detected using brain imaging in the first seven to 14 days following delivery. This review also shines a light on reliable methods for identifying IVH in premature newborns like cranial ultrasound and magnetic resonance imaging along with the treatment of IVH which is primarily supportive and involves the management of intracranial pressure, the correction of coagulation abnormalities, and the prevention of seizures.
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页数:6
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