Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice

被引：10

作者：

Nishina, Takashi ^{[1
]}

Deguchi, Yutaka ^{[1
]}

Kawauchi, Mika ^{[1
]}

Chen, Xiyu ^{[1
,2
]}

Yamazaki, Soh ^{[1
]}

Mikami, Tetuo ^{[3
]}

Nakano, Hiroyasu ^{[1
,4
]}

机构：

[1] Toho Univ, Dept Biochem, Sch Med, 5-21-16 Omori Nishi,Ota Ku, Tokyo 1438540, Japan

[2] Tokyo Coll Biotechnol, 1-3-14 Kitakoujiya,Ota Ku, Tokyo 1440032, Japan

[3] Toho Univ, Dept Pathol, Sch Med, 5-21-16 Omori Nishi,Ota Ku, Tokyo 1438540, Japan

[4] Toho Univ, Host Def Res Ctr, Sch Med, 5-21-16 Omori Nishi,Ota Ku, Tokyo 1438540, Japan

来源：

ISCIENCE | 2023年 / 26卷 / 02期

基金：

日本学术振兴会;

关键词：

INTESTINAL EPITHELIAL-CELLS; ROR-GAMMA-T; ULCERATIVE-COLITIS; GROWTH-FACTOR; GENE; INFLAMMATION; HOMEOSTASIS; EXPRESSION; PROTECTION; POLYMORPHISM;

D O I：

10.1016/j.isci.2023.105934

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Intestinal homeostasis is tightly regulated by epithelial cells, leukocytes, and stro-mal cells, and its dysregulation is associated with inflammatory bowel diseases. Interleukin (IL)-11, a member of the IL-6 family of cytokines, is produced by inflammatory fibroblasts during acute colitis. However, the role of IL-11 in the development of colitis is still unclear. Herein, we showed that IL-11 ameliorated DSS-induced acute colitis in mouse models. We found that deletion of Il11ra1 or Il11 rendered mice highly susceptible to DSS-induced colitis compared to the respective control mice. The number of apoptotic epithelial cells was increased in DSS-treated Il11ra1-or Il11-deficient mice. Moreover, we showed that IL-11 production was regulated by reactive oxygen species (ROS) produced by lyso-zyme M-positive myeloid cells. These findings indicate that fibroblast-produced IL-11 plays an important role in protecting the mucosal epithelium in acute colitis. Myeloid cell-derived ROS contribute to the attenuation of colitis through the pro-duction of IL-11.

引用

页数：23

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