Nylon-6-Coated Doxorubicin-Loaded Magnetic Nanoparticles and Nanocapsules for Cancer Treatment

被引:15
作者
Kovrigina, Ekaterina [1 ]
Poletaeva, Yuliya [1 ]
Zheng, Yanfang [2 ]
Chubarov, Alexey [1 ]
Dmitrienko, Elena [1 ]
机构
[1] RAS, SB, Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia
[2] Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Guangzhou 510095, Peoples R China
关键词
iron oxide nanoparticles; nylon; 6; nanocapsules; polymer nanocomposites; doxorubicin; coatings; pH stimuli response; drug delivery; toxicity; cancer treatment; MESOPOROUS SILICA NANOPARTICLES; IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; IN-VITRO; CAPSULES; NANOPLATFORM; CHITOSAN; THERAPY;
D O I
10.3390/magnetochemistry9040106
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Nanoplatforms used for the loading of anticancer drugs constitute a promising approach to cancer treatment and reducing the side effects of these drugs. Among the cutting-edge systems used in this area are magnetic nanocomposites (MNCs) and nanocapsules (NCs). MNCs are considered to constitute a smart tool for magnetic-field-guided targeted drug delivery, magnetic resonance imaging, and hyperthermia therapy. Nanocapsules offer great potential due to their ability to control drug-loading capacity, their release efficiency, their stability, and the ease with which their surfaces can be modified. This study proposes a method for the development of nylon-6-coated MNCs and nylon-6 polymeric membrane NCs. A biocompatible nylon-6 polymer was first used for NC synthesis. Oleic-acid-modified and non-modified Fe3O4 nanoparticles were synthesized for the production of nylon-coated MNCs. Dynamic light scattering (DLS), transmission electron microscopy (TEM), and zeta-potential measurements were used to perform size, morphology, and charge analyses. The above-mentioned two types of MNCs were considered templates for the manufacture of nylon nanocapsules, leading to NCs with different charges and structures. The developed oleic-acid-coated nylon-6 MNCs and NCs showed excellent loading values of the chemotherapy drug doxorubicin (DOX) of up to 732 and 943 mu g/mg (DOX/MNC or NC), respectively. On the contrary, the capacity of the nano-construction that was not modified with oleic acid did not exceed 140 mu g/mg. The DOX-loaded nanosystems displayed pH-sensitive drug release properties, for which the highest efficiency was observed at an acidic pH. The series of DOX-loaded MNCs and NCs inhibited A549 and HEK 293FT cell lines, with the lowest IC50 value of 0.31 mu M observed for the nanocapsules, which is a 1.5-fold lower concentration than the free DOX. Therefore, the presented nanoscale systems offer great potential for cancer treatment.
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页数:16
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