Access to CF2COR-Containing Quinazolinones via Visible-Light-Induced Domino Difluoroalkylation/Cyclization of N-Cyanamide Alkenes

被引：15

作者：

Cui, Yangyang ^{[1
]}

Xu, Wen ^{[1
]}

Yang, Wenchao ^{[1
]}

Meng, Fei ^{[1
]}

机构：

[1] Yangzhou Univ, Inst Pesticide, Coll Plant Protect, Yangzhou 225009, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 10期

关键词：

RADICAL CYCLIZATION; CASCADE; ALKALOIDS; FUNCTIONALIZATION; DERIVATIVES; CHEMISTRY; ANALOGS;

D O I：

10.1021/acs.orglett.4c00457

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A green and highly efficient visible-light-induced radical cascade difluoroalkylation/cyclization reaction of N-cyanamide alkenes has been developed. A variety of CF2COR-containing quinazolinones have been obtained in high yields with cheap non-metallic 4CzIPN as the photocatalyst. This photocatalytic reaction provides rapid, facile, and practical access to valuable polycyclic quinazolinone, and it is amenable to the gram scale.

引用

页码：2119 / 2123

页数：5