Access to CF2COR-Containing Quinazolinones via Visible-Light-Induced Domino Difluoroalkylation/Cyclization of N-Cyanamide Alkenes

被引：14
|
作者：
Cui, Yangyang [1 ]
Xu, Wen [1 ]
Yang, Wenchao [1 ]
Meng, Fei [1 ]
机构：
[1] Yangzhou Univ, Inst Pesticide, Coll Plant Protect, Yangzhou 225009, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 10期
关键词：
RADICAL CYCLIZATION; CASCADE; ALKALOIDS; FUNCTIONALIZATION; DERIVATIVES; CHEMISTRY; ANALOGS;
D O I：
10.1021/acs.orglett.4c00457
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A green and highly efficient visible-light-induced radical cascade difluoroalkylation/cyclization reaction of N-cyanamide alkenes has been developed. A variety of CF2COR-containing quinazolinones have been obtained in high yields with cheap non-metallic 4CzIPN as the photocatalyst. This photocatalytic reaction provides rapid, facile, and practical access to valuable polycyclic quinazolinone, and it is amenable to the gram scale.
引用
收藏
页码：2119 / 2123
页数：5
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