Interleukins: pathophysiological role in acute pancreatitis

被引：9
作者：
Rafaqat, Saira [1 ]
Patoulias, Dimitrios [2 ]
Behnoush, Amir Hossein [3 ]
Sharif, Saima [1 ]
Klisic, Aleksandra [4 ,5 ,6 ]
机构：
[1] Lahore Coll Women Univ, Dept Zool, Lahore, Punjab, Pakistan
[2] Aristotle Univ Thessaloniki, Gen Hosp Hippokrat, Outpatient Dept Cardiometab Med, Dept Cardiol 2, Thessaloniki, Greece
[3] Univ Tehran Med Sci, Sch Med, Tehran, Iran
[4] Univ Montenegro, Fac Med, Podgorica, Montenegro
[5] Primary Hlth Care Ctr, Ctr Lab Diagnost, Podgorica, Montenegro
[6] Univ Montenegro, Fac Med, Ctr Lab Diagnost, Primary Hlth Care Ctr, Trg Nikole Kovacev 6, Podgorica 81000, Montenegro
来源：
ARCHIVES OF MEDICAL SCIENCE | 2024年 / 20卷 / 01期
关键词：
inflammation; interleukins; acute pancreatitis; pathogenesis; SERUM INTERLEUKIN-10; RECEPTOR ANTAGONIST; DECREASES SEVERITY; T-CELLS; EXPRESSION; FAMILY; ACTIVATION; NECROSIS; GENES; INFLAMMATION;
D O I：
10.5114/aoms/178183
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Acute pancreatitis (AP) is a common inflammatory state characterized by a clinical course that can lead to serious local and extrapancreatic organ malfunction and failure. Interleukins (ILs) are biologically active glycoproteins primarily produced by macrophages and lymphocytes. According to the literature, there are many ILs. However, this article represents a summary of the role of ILs in AP, such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, IL-19, and IL-20. The ways to modulate IL activity to reduce inflammation and improve outcomes in individuals with this condition are under investigation. Drugs that target specific ILs might be developed to mitigate the effects of AP.
引用
收藏
页码：138 / 156
页数：19
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