Cost-effectiveness analysis of grass pollen specific immunotherapy in children with allergic rhinitis compared to the standard of care symptomatic treatment in Portugal

被引：2
作者：
Farraia, Mariana [1 ,2 ,3 ,6 ]
Paciencia, Ines [1 ,2 ]
Mendes, Francisca castro [1 ,2 ,3 ]
Rufo, Joao cavaleiro [1 ,2 ]
Delgado, Luis [3 ,4 ]
Moreira, Andre [1 ,2 ,3 ,5 ]
机构：
[1] Univ Porto, Inst Publ Hlth, EPIUnit, Porto, Portugal
[2] Lab Integrat & Translat Res Populat Hlth ITR, Porto, Portugal
[3] Univ Porto, Fac Med, Dept Pathol, Basic & Clin Immunol Unit, Porto, Portugal
[4] Univ Porto, Fac Med, CINTESIS Ctr Hlth Technol & Serv Res CINTESIS RISE, Porto, Portugal
[5] Sao Joao Univ Hosp Ctr, Porto, Portugal
[6] Univ Porto, Inst Publ Hlth, Rua Taipas 135, P-4050091 Porto, Portugal
来源：
EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY | 2023年 / 55卷 / 05期
关键词：
Allergen immunotherapy; allergic rhinitis; children; cost-effectiveness; grass pollen; SUBLINGUAL IMMUNOTHERAPY; ASTHMA; SLIT;
D O I：
10.23822/EurAnnACI.1764-1489.240
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Background. Cost-effectiveness studies evaluating allergen immunothera-py (AIT) in children are scarce. We aim to compare the cost-effectiveness of subcutaneous (SCIT) and sublingual immunotherapy (SLIT) against stan-dard-of-care (SOC) treatment in children with grass pollen allergic rhinitis. Methods. We created a Markov model to compare the three strategies over a 10-year horizon. SOC was the reference to calculate the incremental cost-ef-fectiveness ratio (ICER). Deterministic and probabilistic sensitivity analysis were used to assess models' uncertainty. Results. We obtained an ICER of 12,605euro and 6,318euro for SLIT and SCIT, respectively. In sensitivity analysis, SCIT was more cost-effective than SLIT. Conclusions. AIT is cost-effective in children with grass pollen allergic rhinitis, especially for the subcutaneous route.
引用
收藏
页码：212 / 228
页数：17
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