Neutrophils as potential therapeutic targets for breast cancer

被引:13
作者
Gong, Yi-Ting [1 ,3 ]
Zhang, Li -Jun [1 ]
Liu, Yi-Chen [1 ]
Tang, Min [1 ]
Lin, Jia-Yi [1 ]
Chen, Xin-Yi [1 ]
Chen, Yi-Xu [1 ]
Yan, Yue [1 ]
Zhang, Wei-Dong [1 ,2 ,3 ]
Jin, Jin-Mei [1 ]
Luan, Xin [1 ]
机构
[1] Shanghai Univ Tradit Chinese Med, Shanghai Frontiers Sci Ctr Chinese Med Chem Biol, Inst Interdisciplinary Integrat Med Res, Shangha 201203, Peoples R China
[2] Second Mil Med Univ, Sch Pharm, Shanghai 201203, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China
基金
上海市科技启明星计划; 中国博士后科学基金;
关键词
Breast cancer; Neutrophils; Metabolic pathway; Immunotherapy; Targeted strategies; TUMOR-ASSOCIATED NEUTROPHILS; FC-ALPHA-RI; POLYMORPHONUCLEAR LEUKOCYTES; LYMPHOCYTE RATIO; MONOCLONAL-ANTIBODY; BONE-MARROW; T-CELLS; RECRUITMENT; PROGNOSIS; GROWTH;
D O I
10.1016/j.phrs.2023.106996
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Breast cancer (BC) remains the foremost cause of cancer mortality globally, with neutrophils playing a critical role in its pathogenesis. As an essential tumor microenvironment (TME) component, neutrophils are emerging as pivotal factors in BC progression. Growing evidence has proved that neutrophils play a Janus- role in BC by polarizing into the anti-tumor (N1) or pro-tumor (N2) phenotype. Clinical trials are evaluating neutrophil-targeted therapies, including Reparixin (NCT02370238) and Tigatuzumab (NCT01307891); however, their clinical efficacy remains suboptimal. This review summarizes the evidence regarding the close relationship between neutrophils and BC, emphasizing the critical roles of neutrophils in regulating metabolic and immune pathways. Additionally, we summarize the existing therapeutic approaches that target neutrophils, highlighting the challenges, and affirming the rationale for continuing to explore neutrophils as a viable therapeutic target in BC management.
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页数:17
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共 184 条
  • [1] Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation
    Adrover, Jose M.
    Aroca-Crevillen, Alejandra
    Crainiciuc, Georgiana
    Ostos, Fernando
    Rojas-Vega, Yeny
    Rubio-Ponce, Andrea
    Cilloniz, Catia
    Bonzon-Kulichenko, Elena
    Calvo, Enrique
    Rico, Daniel
    Moro, Maria A.
    Weber, Christian
    Lizasoain, Ignacio
    Torres, Antoni
    Ruiz-Cabello, Jesus
    Vazquez, Jesus
    Hidalgo, Andres
    [J]. NATURE IMMUNOLOGY, 2020, 21 (02) : 135 - +
  • [2] Diabetes causes marked changes in function and metabolism of rat neutrophils
    Alba-Loureiro, TC
    Hirabara, SM
    Mendonça, JR
    Curi, R
    Pithon-Curi, TC
    [J]. JOURNAL OF ENDOCRINOLOGY, 2006, 188 (02) : 295 - 303
  • [3] 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors
    Allegretti, M
    Bertini, R
    Cesta, MC
    Bizzarri, C
    Di Bitondo, R
    Di Cioccio, V
    Galliera, E
    Berdini, V
    Topai, A
    Zampella, G
    Russo, V
    Di Bello, N
    Nano, G
    Nicolini, L
    Locati, M
    Fantucci, P
    Florio, S
    Colotta, F
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (13) : 4312 - 4331
  • [4] Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics
    Alshetaiwi, Hamad
    Pervolarakis, Nicholas
    McIntyre, Laura Lynn
    Ma, Dennis
    Quy Nguyen
    Rath, Jan Akara
    Nee, Kevin
    Hernandez, Grace
    Evans, Katrina
    Torosian, Leona
    Silva, Anushka
    Walsh, Craig
    Kessenbrock, Kai
    [J]. SCIENCE IMMUNOLOGY, 2020, 5 (44)
  • [5] Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production
    Amini, Poorya
    Stojkov, Darko
    Felser, Andrea
    Jackson, Christopher B.
    Courage, Carolina
    Schaller, Andre
    Gelman, Laurent
    Soriano, Maria Eugenia
    Nuoffer, Jean-Marc
    Scorrano, Luca
    Benarafa, Charaf
    Yousefi, Shida
    Simon, Hans-Uwe
    [J]. NATURE COMMUNICATIONS, 2018, 9
  • [6] Extracellular Vesicles Derived from MDA-MB-231 Cells Trigger Neutrophils to a Pro-Tumor Profile
    Amorim, Carolinne
    Docasar, Clara Luisa
    Guimaraes-Bastos, Daniel
    Frony, Ana Clara
    Barja-Fidalgo, Christina
    Renovato-Martins, Mariana
    Moraes, Joao Alfredo
    [J]. CELLS, 2022, 11 (12)
  • [7] Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human
    Andzinski, Lisa
    Kasnitz, Nadine
    Stahnke, Stephanie
    Wu, Ching-Fang
    Gereke, Marcus
    von Koeckritz-Blickwede, Maren
    Schilling, Bastian
    Brandau, Sven
    Weiss, Siegfried
    Jablonska, Jadwiga
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2016, 138 (08) : 1982 - 1993
  • [8] Directing cancer cells to self-destruct with pro-apoptotic receptor agonists
    Ashkenazi, Avi
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (12) : 1001 - 1012
  • [9] Targeting FcαRI on Polymorphonuclear Cells Induces Tumor Cell Killing through Autophagy
    Bakema, Jantine E.
    Ganzevles, Sonja H.
    Fluitsma, Donna M.
    Schilham, Marco W.
    Beelen, Robert H. J.
    Valerius, Thomas
    Lohse, Stefan
    Glennie, Martin J.
    Medema, Jan Paul
    van Egmond, Marjolein
    [J]. JOURNAL OF IMMUNOLOGY, 2011, 187 (02) : 726 - 732
  • [10] Co-option of Neutrophil Fates by Tissue Environments
    Ballesteros, Ivan
    Rubio-Ponce, Andrea
    Genua, Marco
    Lusito, Eleonora
    Kwok, Immanuel
    Fernandez-Calvo, Gabriel
    Khoyratty, Tariq E.
    van Grinsven, Erinke
    Gonzalez-Hernandez, Sara
    Angel Nicolas-Avila, Jose
    Vicanolo, Tommaso
    Maccataio, Antonio
    Benguria, Alberto
    Li, Jackson LiangYao
    Adrover, Jose M.
    Aroca-Crevillen, Alejandra
    Quintana, Juan A.
    Martin-Salamanca, Sandra
    Mayo, Francisco
    Ascher, Stefanie
    Barbiera, Giulia
    Soehnlein, Oliver
    Gunzer, Matthias
    Ginhoux, Florent
    Sanchez-Cabo, Fatima
    Nistal-Villan, Estanislao
    Schulz, Christian
    Dopazo, Ana
    Reinhardt, Christoph
    Udalova, Irina A.
    Ng, Lai Guan
    Ostuni, Renato
    Hidalgo, Andres
    [J]. CELL, 2020, 183 (05) : 1282 - +