Concentrations of per- and polyfluoroalkyl substances (PFAS) in paired tap water and blood samples during pregnancy

被引：10

作者：

Cserbik, Dora ^{[1
,2
,3
]}

Casas, Maribel ^{[1
,2
,3
]}

Flores, Cintia ^{[4
]}

Paraian, Alexandra ^{[4
]}

Haug, Line Smastuen ^{[5
]}

Rivas, Ioar ^{[1
,2
,3
]}

Bustamante, Mariona ^{[1
,2
,3
]}

Dadvand, Payam ^{[1
,2
,3
]}

Sunyer, Jordi ^{[1
,2
,3
,6
]}

Vrijheid, Martine ^{[1
,2
,3
]}

Villanueva, Cristina M. ^{[1
,2
,3
,6
]}

机构：

[1] ISGlobal, Barcelona, Spain

[2] Univ Pompeu Fabra UPF, Barcelona, Spain

[3] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[4] IDAEA CSIC Barcelona, Inst Environm Assessment & Water Res, Mass Spectrometry Lab Organ Pollutants, Barcelona, Spain

[5] Norwegian Inst Publ Hlth, Ctr Sustainable Diets, Oslo, Norway

[6] Hosp Mar, Med Res Inst, IMIM, Barcelona, Spain

来源：

JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY | 2024年 / 34卷 / 01期

基金：

欧洲研究理事会; 欧盟地平线“2020”;

关键词：

Drinking water; PFAS; Biomonitoring; Exposure assessment; PERFLUOROALKYL SUBSTANCES; PERFLUORINATED COMPOUNDS; PLASMA-CONCENTRATIONS; BIRTH OUTCOMES; DRINKING-WATER; EXPOSURE; WOMEN; ACIDS; COHORT; TRENDS;

D O I：

10.1038/s41370-023-00581-7

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Per- and polyfluoroalkyl substances (PFAS) are water-soluble chemicals of concern due to their persistence, ubiquity, and toxicity. We explored correlations between drinking water and blood PFAS levels in a subset of the mother-child Barcelona Life Study Cohort (BiSC), Barcelona, Spain (2021). For 105 study participants, we analyzed 35 PFAS in tap water (unfiltered and filtered) and 23 PFAS in 98 paired plasma samples during the 3rd trimester, using LC-MS/MS. Water consumption habits were ascertained at the third trimester through questionnaires. The majority of participants consumed bottled water (56.2%), 5/35 PFAS were detected in unfiltered tap water, 4/35 PFAS in activated carbon filtered tap water samples, and 14/23 PFAS in plasma samples. Our results showed that PFHpA at the observed concentrations in drinking water was significantly correlated with paired plasma levels (R = 0.2; p = 0.04).

引用

页码：90 / 96

页数：7

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