Neuronal nuclear tau and neurodegeneration

被引：23

作者：

Anton-Fernandez, Alejandro ^{[1
]}

Valles-Saiz, Laura ^{[1
]}

Avila, Jesus ^{[1
]}

Hernandez, Felix ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, CSIC, UAM, Madrid 28049, Spain

来源：

NEUROSCIENCE | 2023年 / 518卷

关键词：

Aging; Neurodegeneration; Nucleolus; nucleus; nuclear pore; Tau; FRONTOTEMPORAL DEMENTIA; TRANSPOSABLE ELEMENTS; ALZHEIMERS-DISEASE; PROTEIN; MICROTUBULE; GENE; DNA; ARCHITECTURE; MUTATIONS; PHOSPHORYLATION;

D O I：

10.1016/j.neuroscience.2022.07.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

is a well-known microtubule-associated protein related to its cytoplasmic localization in a neuronal cell. However, tau has been located at the cell nucleus where it could be a nucleic acid-associated protein by its preferential binding to DNA sequences present in the nucleolus and pericentromeric heterochromatin. This less well-known localization of tau could not be trivial, since during aging, an increase in the amount of nuclear tau takes place and it may be related to the described role of tau in the activation of transposons and further aging acceleration. This article is part of a Special Issue entitled: SI: The Molecular Bases of Tauopathies. (c) 2022 The Author(s). Published by Elsevier Ltd on behalf of IBRO. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/ 4.0/).

引用

页码：178 / 184

页数：7

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