Mediator structure and function in transcription initiation

被引：6

作者：

Rengachari, Srinivasan ^{[1
]}

Schilbach, Sandra ^{[1
]}

Cramer, Patrick ^{[1
]}

机构：

[1] Max Planck Inst Multidisciplinary Sci, Dept Mol Biol, Fassberg 11, D-37077 Gottingen, Germany

来源：

BIOLOGICAL CHEMISTRY | 2023年 / 404卷 / 8-9期

关键词：

coactivator; gene regulation; mediator; RNA polymerase II; transcription; RNA-POLYMERASE-II; COMPLEX REVEALS; TERMINAL DOMAIN; ARCHITECTURE; SUBUNIT; MODEL; REARRANGEMENTS; ACTIVATION; MUTATION;

D O I：

10.1515/hsz-2023-0158

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent advances in cryo-electron microscopy have led to multiple structures of Mediator in complex with the RNA polymerase II (Pol II) transcription initiation machinery. As a result we now hold in hands near-complete structures of both yeast and human Mediator complexes and have a better understanding of their interactions with the Pol II pre-initiation complex (PIC). Herein, we provide a summary of recent achievements and discuss their implications for future studies of Mediator and its role in gene regulation.

引用

页码：829 / 837

页数：9

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