Mediator structure and function in transcription initiation

被引：5
作者：
Rengachari, Srinivasan [1 ]
Schilbach, Sandra [1 ]
Cramer, Patrick [1 ]
机构：
[1] Max Planck Inst Multidisciplinary Sci, Dept Mol Biol, Fassberg 11, D-37077 Gottingen, Germany
来源：
BIOLOGICAL CHEMISTRY | 2023年 / 404卷 / 8-9期
关键词：
coactivator; gene regulation; mediator; RNA polymerase II; transcription; RNA-POLYMERASE-II; COMPLEX REVEALS; TERMINAL DOMAIN; ARCHITECTURE; SUBUNIT; MODEL; REARRANGEMENTS; ACTIVATION; MUTATION;
D O I：
10.1515/hsz-2023-0158
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent advances in cryo-electron microscopy have led to multiple structures of Mediator in complex with the RNA polymerase II (Pol II) transcription initiation machinery. As a result we now hold in hands near-complete structures of both yeast and human Mediator complexes and have a better understanding of their interactions with the Pol II pre-initiation complex (PIC). Herein, we provide a summary of recent achievements and discuss their implications for future studies of Mediator and its role in gene regulation.
引用
收藏
页码：829 / 837
页数：9
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