Detection of Culex tritaeniorhynchus Giles and Novel Recombinant Strain of Lumpy Skin Disease Virus Causes High Mortality in Yaks

被引:12
|
作者
Li, Yan [1 ]
Zeng, Zhibo [1 ]
Li, Kewei [1 ]
Rehman, Mujeeb Ur [2 ]
Nawaz, Shah [1 ]
Kulyar, Muhammad Fakhar-e-Alam [1 ]
Hu, Miao [1 ]
Zhang, Wenqian [1 ]
Zhang, Zhao [1 ]
An, Miao [1 ]
Hu, Jianwu [1 ,3 ]
Li, Jiakui [1 ]
机构
[1] Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Peoples R China
[2] Livestock & Dairy Dev Dept, Dis Invest Lab, Zhob 85200, Pakistan
[3] Tibet Autonomous Reg Vet Bur, Agr & Rural Affairs Dept, Lhasa 850000, Peoples R China
来源
VIRUSES-BASEL | 2023年 / 15卷 / 04期
关键词
yak; lumpy skin disease virus; vaccine-related recombinant; Culex tritaeniorhynchus Giles;
D O I
10.3390/v15040880
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Lumpy skin disease virus (LSDV) is capable of causing transboundary diseases characterized by fever, nodules on the skin, mucous membranes, and inner organs. The disease may cause emaciation with the enlargement of lymph nodes and sometimes death. It has had endemic importance in various parts of Asia in recent years, causing substantial economic losses to the cattle industry. The current study reported a suspected LSDV infection (based on signs and symptoms) from a mixed farm of yak and cattle in Sichuan Province, China. The clinical samples were found positive for LSDV using qPCR and ELISA, while LSDV DNA was detected in Culex tritaeniorhynchus Giles. The complete genome sequence of China/LSDV/SiC/2021 was determined by Next-generation sequencing. It was found that China/LSDV/SiC/2021 is highly homologous to the novel vaccine-related recombinant LSDV currently emerging in China and countries surrounding China. Phylogenetic tree analysis revealed that the novel vaccine-associated recombinant LSDV formed a unique dendrograms topology between field and vaccine-associated strains. China/LSDV/SiC/2021 was found to be a novel recombinant strain, with at least 18 recombination events via field viruses identified in the genome sequence. These results suggest that recombinant LSDV can cause high mortality in yaks, and its transmission might be due to the Culex tritaeniorhynchus Giles, which acts as a mechanical vector.
引用
收藏
页数:7
相关论文
共 9 条
  • [1] Infection, dissemination, and transmission of lumpy skin disease virus in Aedes aegypti (Linnaeus), Culex tritaeniorhynchus ( Giles ), and Culex quinquefasciatus (Say) mosquitoes
    Riana, Elizabeth
    Sri-In, Chalida
    Songkasupa, Tapanut
    Bartholomay, Lyric C.
    Thontiravong, Aunyaratana
    Tiawsirisup, Sonthaya
    ACTA TROPICA, 2024, 254
  • [2] A novel strain of lumpy skin disease virus causes clinical disease in cattle in Hong Kong
    Flannery, John
    Shih, Barbara
    Haga, Ismar R.
    Ashby, Martin
    Corla, Amanda
    King, Simon
    Freimanis, Graham
    Polo, Noemi
    Tse, Anne Ching-Nga
    Brackman, Christopher J.
    Chan, Jason
    Pun, Patrick
    Ferguson, Andrew D.
    Law, Andy
    Lycett, Samantha
    Batten, Carrie
    Beard, Philippa M.
    TRANSBOUNDARY AND EMERGING DISEASES, 2021, : e336 - e343
  • [3] Immunogenicity of a recombinant lumpy skin disease virus (neethling vaccine strain) expressing the rabies virus glycoprotein in cattle
    Aspden, K
    van Dijk, AA
    Bingham, J
    Cox, D
    Passmore, JA
    Williamson, AL
    VACCINE, 2002, 20 (21-22) : 2693 - 2701
  • [4] Subclinical infection caused by a recombinant vaccine-like strain poses high risks of lumpy skin disease virus transmission
    Shumilova, Irina
    Prutnikov, Pavel
    Mazloum, Ali
    Krotova, Alena
    Tenitilov, Nikita
    Byadovskaya, Olga
    Chvala, Ilya
    Prokhvatilova, Larisa
    Sprygin, Alexander
    FRONTIERS IN VETERINARY SCIENCE, 2024, 11
  • [5] Molecular characterization of a novel subgenotype of lumpy skin disease virus strain isolated in Inner Mongolia of China
    Xiaohui Zan
    Haibi Huang
    Yu Guo
    Dongdong Di
    Cun Fu
    Shirong Wang
    Youzhi Wu
    Jialei Wang
    Yan Wang
    Yanhua Ma
    Chunxia Chai
    Rui Su
    Qingqing Song
    Wei Wang
    BMC Veterinary Research, 18
  • [6] Molecular characterization of a novel recombinant lumpy skin disease virus isolated during an outbreak in Tyumen, Russia, in 2019
    Krotova, Alena
    Byadovskaya, Olga
    Shumilova, Irina
    Zinyakov, Nikolay
    van Schalkwyk, Antoinette
    Sprygin, Alexander
    TRANSBOUNDARY AND EMERGING DISEASES, 2022, 69 (05) : E2312 - E2317
  • [7] Molecular characterization of a novel subgenotype of lumpy skin disease virus strain isolated in Inner Mongolia of China
    Zan, Xiaohui
    Huang, Haibi
    Guo, Yu
    Di, Dongdong
    Fu, Cun
    Wang, Shirong
    Wu, Youzhi
    Wang, Jialei
    Wang, Yan
    Ma, Yanhua
    Chai, Chunxia
    Su, Rui
    Song, Qingqing
    Wang, Wei
    BMC VETERINARY RESEARCH, 2022, 18 (01)
  • [8] Evaluation of recombinant extracellular enveloped virion protein candidates for the detection of serological responses to lumpy skin disease virus in cattle
    Angsujinda, Kitipong
    Kitchanakan, Phatpimol
    Daewang, Nabhasbhichayabha
    Chintapitaksakul, Lerdchai
    Wanganurakkul, Saruda
    Chaiyo, Sudkate
    Khongchareonporn, Nanthika
    Mahony, Timothy J.
    Assavalapsakul, Wanchai
    VETERINARY QUARTERLY, 2025, 45 (01) : 1 - 13
  • [9] Development of a Multi-Locus Real-Time PCR with a High-Resolution Melting Assay to Differentiate Wild-Type, Asian Recombinant, and Vaccine Strains of Lumpy Skin Disease Virus
    Bhakha, Kultyarat
    Matsui, Yuto
    Buakhao, Natchaya
    Wanganurakkul, Saruda
    Deemagarn, Taweewat
    Oba, Mami
    Takemae, Hitoshi
    Mizutani, Tetsuya
    Misawa, Naoaki
    Chintapitaksakul, Lerdchai
    Yamada, Kentaro
    Suwankitwat, Nutthakarn
    VETERINARY SCIENCES, 2025, 12 (03)