Disease activity in patients with immune-mediated inflammatory diseases after SARS-CoV-2 vaccinations

被引：13

作者：

van Dam, Koos P. J. ^{[1
]}

Wieske, Luuk ^{[1
,2
]}

Stalman, Eileen W. ^{[1
]}

Kummer, Laura Y. L. ^{[1
,3
]}

Roosen, Jesse ^{[1
]}

van Kempen, Zoe L. E. ^{[4
]}

Killestein, Joep ^{[4
]}

Volkers, Adriaan G. ^{[5
]}

Boekel, Laura ^{[6
]}

Wolbink, Gerrit J. ^{[6
]}

van der Kooi, Anneke J. ^{[1
]}

Raaphorst, Joost ^{[1
]}

Lowenberg, Mark ^{[5
]}

Takkenberg, R. Bart ^{[5
]}

D'Haens, Geert R. A. M. ^{[5
]}

Spuls, Phyllis I. ^{[7
]}

Bekkenk, Marcel W. ^{[7
]}

Musters, Annelie H. ^{[7
]}

Post, Nicoline F. ^{[7
]}

Bosma, Angela L. ^{[7
]}

Hilhorst, Marc L. ^{[8
]}

Vegting, Yosta ^{[8
]}

Bemelman, Frederike J. ^{[8
]}

Voskuyl, Alexandre E. ^{[9
]}

Broens, Bo ^{[9
]}

Sanchez, Agner Parra ^{[9
,10
]}

van Els, Cecile A. C. M. ^{[11
,12
]}

de Wit, Jelle ^{[11
]}

Rutgers, Abraham ^{[13
]}

de Leeuw, Karina ^{[13
]}

Horvath, Barbara ^{[14
]}

Verschuuren, Jan J. G. M. ^{[15
]}

Ruiter, Annabel M. ^{[15
]}

van Ouwerkerk, Lotte ^{[16
]}

van der Woude, Diane ^{[16
]}

Allaart, Renee C. F. ^{[16
]}

Teng, Y. K. Onno ^{[17
]}

van Paassen, Pieter ^{[18
]}

Busch, Matthias H. ^{[18
]}

Jallah, Papay B. P. ^{[18
]}

Brusse, Esther ^{[19
]}

van Doorn, Pieter A. ^{[19
]}

Baars, Adaja E. ^{[19
]}

Hijnen, Dirk Jan ^{[20
]}

Schreurs, Corine R. G. ^{[20
]}

van der Pol, W. Ludo ^{[21
]}

Goedee, H. Stephan ^{[21
]}

Steenhuis, Maurice ^{[3
]}

Keijzer, Sofie ^{[3
]}

Keijser, Jim B. D. ^{[3
]}

机构：

[1] Univ Amsterdam, Dept Neurol & Neurophysiol, Amsterdam Neurosci, Amsterdam UMC, Amsterdam, Netherlands

[2] St Antonius Hosp, Dept Clin Neurophysiol, Nieuwegein, Netherlands

[3] Amsterdam UMC, Dept Immunopathol, Sanquin Res & Landsteiner Lab, Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Dept Neurol, Amsterdam UMC, Med Ctr, Amsterdam, Netherlands

[5] Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol & Hepatol, Amsterdam UMC, Amsterdam, Netherlands

[6] Reade, Amsterdam Rheumatol & Immunol Ctr, Dept Rheumatol, Amsterdam, Netherlands

[7] Univ Amsterdam, Acad Med Ctr, Dept Dermatol, Amsterdam UMC, Amsterdam, Netherlands

[8] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Sect Nephrol, Amsterdam, Netherlands

[9] Vrije Univ Amsterdam, Amsterdam Rheumatol & Immunol Ctr, Dept Rheumatol & Clin Immunol, Med Ctr, Amsterdam, Netherlands

[10] Univ Amsterdam, Amsterdam Rheumatol & Immunol Ctr, Dept Rheumatol & Clin Immunol, Amsterdam UMC, Amsterdam, Netherlands

[11] Natl Inst Publ Hlth & Environm RIVM, Ctr Infect Dis Control, Bilthoven, Netherlands

[12] Univ Utrecht, Fac Vet Med, Utrecht, Netherlands

[13] Univ Med Ctr Groningen, Dept Rheumatol & Clin Immunol, Groningen, Netherlands

[14] Univ Groningen, Univ Med Ctr Groningen, Ctr Blistering Dis, Dept Dermatol, Groningen, Netherlands

[15] Leiden Univ, Dept Neurol, Med Ctr, Leiden, Netherlands

[16] Leiden Univ, Dept Rheumatol, Med Ctr, Leiden, Netherlands

[17] Leiden Univ, Ctr Expertise Lupus Vasculitis & Complement Media, Dept Internal Med Nephrol Sect, Med Ctr, Leiden, Netherlands

[18] Maastricht Univ, Dept Nephrol & Clin Immunol, Med Ctr, Maastricht, Netherlands

[19] Univ Med Ctr, Dept Neurol, Erasmus MC, Rotterdam, Netherlands

[20] Univ Med Ctr, Dept Dermatol, Erasmus MC, Rotterdam, Netherlands

[21] UMC Utrecht, Dept Neurol & Neurosurg, Brain Ctr, Utrecht, Netherlands

[22] Univ Amsterdam, Swammerdam Inst Life Sci, Amsterdam, Netherlands

[23] Univ Amsterdam, Dept Pediat Immunol Rheumatol & Infect Dis, Amsterdam UMC, AMC, Amsterdam, Netherlands

来源：

JOURNAL OF AUTOIMMUNITY | 2023年 / 135卷

关键词：

SARS-CoV-2; COVID-19; Vaccination; Autoimmune disease; Disease activity; Flare;

D O I：

10.1016/j.jaut.2022.102984

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

For patients with immune-mediated inflammatory diseases (IMIDs), concerns exist about increased disease ac-tivity after vaccination. We aimed to assess changes in disease activity after SARS-CoV-2 vaccination in patients with IMIDs, and determine risk factors for increased disease activity. In this substudy of a prospective obser-vational cohort study (Target-to-B!), we included patients with IMIDs who received a SARS-CoV-2 vaccine. Patients reported changes in disease activity on a five-point Likert scale every 60 days for up to twelve months after first vaccination. In case of self-reported increased activity, hospital records were screened whether the treating physician reported increased activity, and for potential intensification of immunosuppressive (ISP) treatment. Mixed models were used to study determinants for self-reported increased disease activity. In total, 2111 patients were included for analysis after primary immunization (mean age 49.7 years [SD 13.7], 1329/ 2111 (63.0%) female), from which 1266 patients for analysis after first additional vaccination. Increased disease activity at 60 days after start of primary immunization was reported by 223/2111 (10.6%). In 96/223 (43.0%) the increase was confirmed by the treating physician and in 36/223 (16.1%) ISP treatment was intensified. Increased disease activity at seven to 60 days after additional vaccination, was reported by 139/1266 (11.0%). Vaccinations were not temporally associated with self-reported increased disease activity. Conversely, increased disease activity before first vaccination, neuromuscular disease, and multiple sclerosis were associated. Alto-gether, self-reported increased disease activity after vaccination against SARS-CoV-2 was recorded in a minority of patients and was generally mild. Moreover, multivariate analyses suggest that disease related factors, but not vaccinations are the major determinants for self-reported increased disease activity.

引用

页数：9

共 23 条

[1] Association between obesity and remission in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs
Abuhelwa, Ahmad Y.
Hopkins, Ashley M.
Sorich, Michael J.
Proudman, Susanna
Foster, David J. R.
Wiese, Michael D.
[J]. SCIENTIFIC REPORTS, 2020, 10 (01)
[2] SARS-CoV-2 Vaccination Safety in Guillain-Barre Syndrome, Chronic Inflammatory Demyelinating Polyneuropathy, and Multifocal Motor Neuropathy
Baars, Adaja E.
Kuitwaard, Krista
de Koning, Laura C.
Luijten, Linda W. G.
Kok, W. Maaike
Eftimov, Filip
Wieske, Luuk
Goedee, H. Stephan
van der Pol, W. Ludo
Blomkwist-Markens, Patricia H.
Horemans, Anja M. C.
Jacobs, Bart C.
van Doorn, Pieter A.
[J]. NEUROLOGY, 2023, 100 (02) : E182 - E191
[3] Breakthrough SARS-CoV-2 infections with the delta (B.1.617.2) variant in vaccinated patients with immune-mediated inflammatory diseases using immunosuppressants: a substudy of two prospective cohort studies
Boekel, Laura
Stalman, Eileen W.
Wieske, Luuk
Hooijberg, Femke
van Dam, Koos P. J.
Besten, Yaelle R.
Kummer, Laura Y. L.
Steenhuis, Maurice
van Kempen, Zoe L. E.
Killestein, Joep
Volkers, Adriaan G.
Tas, Sander W.
van der Kooi, Anneke J.
Raaphorst, Joost
Lowenberg, Mark
Takkenberg, R. Bart
D'Haens, Geert R. A. M.
Spuls, Phyllis, I
Bekkenk, Marcel W.
Musters, Annelie H.
Post, Nicoline F.
Bosma, Angela L.
Hilhorst, Marc L.
Vegting, Yosta
Bemelman, Frederike J.
Voskuyl, Alexandre E.
Broens, Bo
Sanchez, Agner Parra
van Els, Cecile A. C. M.
de Wit, Jelle
Rutgers, Abraham
de Leeuw, Karina
Horvath, Barbara
Verschuuren, Jan J. G. M.
Ruiter, Annabel M.
van Ouwerkerk, Lotte
van der Woude, Diane
Allaart, Cornelia F.
Teng, Y. K. Onno
van Paassen, Pieter
Busch, Matthias H.
Jallah, Papay B. P.
Brusse, Esther
van Doorn, Pieter A.
Baars, Adaja E.
Hijnen, Dirk Jan
Schreurs, Corine R. G.
van der Pol, W. Ludo
Goedee, H. Stephan
Vogelzang, Erik H.
[J]. LANCET RHEUMATOLOGY, 2022, 4 (06) : E417 - E429
[4] Adverse events after first COVID-19 vaccination in patients with autoimmune diseases
Boekel, Laura
Kummer, Laura Y.
van Dam, Koos P. J.
Hooijberg, Femke
van Kempen, Zoe
Vogelzang, Erik H.
Wieske, Luuk
Eftimov, Filip
van Vollenhoven, Ronald
Kuijpers, Taco W.
van Ham, S. Marieke
Tas, Sander W.
Killestein, Joep
Boers, Maarten
Nurmohamed, Mike T.
Rispens, Theo
Wolbink, Gertjan
[J]. LANCET RHEUMATOLOGY, 2021, 3 (08) : E541 - E545
[5] Perspective of patients with autoimmune diseases on COVID-19 vaccination
Boekel, Laura
Hooijberg, Femke
van Kempen, Zoe L. E.
Vogelzang, Erik H.
Tas, Sander W.
Killestein, Joep
Nurmohamed, Michael T.
Boers, Maarten
Kuijpers, Taco W.
van Ham, S. Marieke
Eftimov, Filip
Wieske, Luuk
Rispens, Theo
Wolbink, Gertjan J.
[J]. LANCET RHEUMATOLOGY, 2021, 3 (04) : E241 - E243
[6] Disease Flare and Reactogenicity in Patients With Rheumatic and Musculoskeletal Diseases Following Two-Dose SARS-CoV-2 Messenger RNA Vaccination
Connolly, Caoilfhionn M.
Ruddy, Jake A.
Boyarsky, Brian J.
Barbur, Iulia
Werbel, William A.
Geetha, Duvuru
Garonzik-Wang, Jacqueline M.
Segev, Dorry L.
Christopher-Stine, Lisa
Paik, Julie J.
[J]. ARTHRITIS & RHEUMATOLOGY, 2022, 74 (01) : 28 - 32
[7] De Gier B., 2021, EUROSURVEILLANCE, V26, P1, DOI [10.2807/1560-7917.ES.2021, DOI 10.2807/1560-7917.ES.2021]
[8] BNT162b2 mRNA COVID-19 vaccine three-dose safety and risk of COVID-19 in patients with myasthenia gravis during the alpha, delta, and omicron waves
Doron, Alon
Piura, Yoav
Vigiser, Ifat
Kolb, Hadar
Regev, Keren
Nesher, Nahum
Karni, Arnon
[J]. JOURNAL OF NEUROLOGY, 2022, 269 (12) : 6193 - 6201
[9] Vaccination Against SARS-CoV-2 in Neuroinflammatory Disease: Early Safety/Tolerability Data
Epstein, Samantha
Xia, Zongqi
Lee, Annie J.
Dahl, Megan
Edwards, Keith
Levit, Elle
Longbrake, Erin E.
Perrone, Christopher
Kavak, Katelyn
Weinstock-Guttman, Bianca
Diallo, Fatoumata
Ricci, Adelle
Riley, Claire S.
De Jager, Philip L.
Farber, Rebecca
Wesley, Sarah F.
[J]. MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2022, 57
[10] Impact of Obesity on Disease Activity and Patient-Reported Outcomes Measurement Information System (PROMIS) in Inflammatory Bowel Diseases
Jain, Animesh
Nguyen, Nghia H.
Proudfoot, James A.
Martin, Christopher F.
Sandborn, William J.
Kappelman, Michael D.
Long, Millie D.
Singh, Siddharth
[J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2019, 114 (04) : 630 - 639

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