The effects of natural products and bioactive ingredients of traditional Chinese medicine on apoptosis of ovarian granulosa cells

被引：1
作者：
Zhong, Lulu [1 ,2 ]
Luo, Yue [3 ]
Zhou, Feng [1 ,2 ]
Yang, Xuebin [1 ,2 ]
Tan, Yang [1 ,2 ]
Li, Shunmin [4 ]
Pei, Gang [1 ,2 ]
机构：
[1] Hunan Univ Chinese Med, Pharm Coll, Changsha, Peoples R China
[2] Educ Dept Hunan Prov, Key Lab Modern Res TCM, Changsha, Peoples R China
[3] Liuyang Peoples Hosp, Dept Pharm, Changsha, Peoples R China
[4] Shenzhen Tradit Chinese Med Hosp, Shenzhen, Peoples R China
来源：
JOURNAL OF APPLIED TOXICOLOGY | 2023年 / 43卷 / 06期
关键词：
apoptosis; female reproductive toxicity; natural products; ovarian granulosa cell; traditional Chinese medicine; ENDOPLASMIC-RETICULUM STRESS; FOLLICLE-STIMULATING-HORMONE; OXIDATIVE STRESS; RECEPTOR SYSTEM; DEATH LIGAND; FAS LIGAND; ATRESIA; EXPRESSION; PROLIFERATION; ACTIVATION;
D O I：
10.1002/jat.4406
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Abnormal ovarian function is the main manifestation of female reproductive toxicity. Granulosa cells (GCs) play an important role in determining the fate of follicles and are the main effector cells of the female reproductive system. Excessive apoptosis of GCs leads to pathological folliculogenesis and further reproductive damage. However, drugs available for treatment of female reproductive toxicity are limited. Recent studies have confirmed that various natural products and bioactive ingredients of traditional Chinese medicine (TCM) can inhibit apoptosis of GCs and protect ovarian function. In this review, the mechanisms underlying the proapoptotic and antiapoptotic effects of natural products and bioactive ingredients of TCM on the proliferation, function, and apoptosis of GCs are summarized based on the findings of reports published over the past 10 years as reference for the treatment of female reproductive toxicity.
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收藏
页码：772 / 788
页数：17
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