A convergent structure-function substrate of cognitive imbalances in autism

被引：7

作者：

Hong, Seok-Jun ^{[1
,2
,3
,4
,5
]}

Mottron, Laurent ^{[6
,7
]}

Park, Bo-Yong ^{[1
,2
,3
,8
]}

Benkarim, Oualid ^{[1
,2
]}

Valk, Sofie L. ^{[1
,2
,9
,10
,11
]}

Paquola, Casey ^{[1
,2
,10
]}

Lariviere, Sara ^{[1
,2
]}

de Wael, Reinder Vos ^{[1
,2
]}

Degre-Pelletier, Janie ^{[1
,2
,12
]}

Soulieres, Isabelle ^{[12
]}

Ramphal, Bruce ^{[13
,14
]}

Margolis, Amy ^{[13
,14
]}

Milham, Michael ^{[5
,15
]}

Di Martino, Adriana ^{[16
]}

Bernhardt, Boris C. ^{[1
,2
]}

机构：

[1] McGill Univ, Dept Neurol & Neurosurg, McConnell Brain Imaging Ctr, Multimodal Imaging & Connectome Anal Lab, 3801 Univ St, Montreal, PQ H3A 2B4, Canada

[2] McGill Univ, Montreal Neurol Inst & Hosp, 3801 Univ St, Montreal, PQ H3A 2B4, Canada

[3] Sungkyunkwan Univ, Ctr Neurosci Imaging Res, Inst Basic Sci, Seobu Ro 2066, Suwon 16419, South Korea

[4] Sungkyunkwan Univ, Dept Biomed Engn, Seobu Ro 2066, Suwon 16419, South Korea

[5] Child Mind Inst, Ctr Developing Brain, 101 East 56th St, New York, NY 10022 USA

[6] Univ Montreal, Ctr Rech CIUSSSNIM, 7070 Blvd Perras, Montreal, PQ H1E 1A4, Canada

[7] Univ Montreal, Dept Psychiat & Addictol, 7070 Blvd Perras, Montreal, PQ H1E 1A4, Canada

[8] Inha Univ, Dept Data Sci, Incheon 22212, South Korea

[9] Max Planck Inst Human Cognit & Brain Sci, Otto Hahn Grp Cognit Neurogenet, Stephanstr 1A, D-04103 Leipzig, Germany

[10] Res Ctr Wilhelm Johnen Str, Inst Neurosci & Med, D-52425 Julich, Germany

[11] Heinrich Heine Univ, Inst Syst Neurosci, Moorenstr 5, D-40225 Dusseldorf, Germany

[12] Univ Quebec Montreal, Dept Psychol, 100 Rue Sherbrooke Ouest, Montreal, PQ H2X 3P2, Canada

[13] Columbia Univ, New York State Psychiat Inst, Dept Psychiat, 1051 Riverside Dr, New York, NY 10032 USA

[14] Columbia Univ, Coll Phys Surg, 1051 Riverside Dr, New York, NY 10032 USA

[15] Nathan S Kline Inst Psychiat Res, Ctr Biomed Imaging & Neuromodulat, 140 Old Orangeburg Rd, Orangeburg, NY 10962 USA

[16] Child Mind Inst, Autism Ctr, 101 East 56th St, New York, NY 10022 USA

来源：

CEREBRAL CORTEX | 2023年 / 33卷 / 05期

基金：

新加坡国家研究基金会; 加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

autism; verbal and nonverbal IQ; multimodal neuroimaging; neurosubtyping; cognitive imbalance; SPECTRUM DISORDER; CORTICAL THICKNESS; WHITE-MATTER; CONNECTIVITY; CHILDREN; BRAIN; LANGUAGE; MRI; LATERALIZATION; CONNECTOME;

D O I：

10.1093/cercor/bhac156

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background Autism spectrum disorder (ASD) is a common neurodevelopmental diagnosis showing substantial phenotypic heterogeneity. A leading example can be found in verbal and nonverbal cognitive skills, which vary from elevated to impaired compared with neurotypical individuals. Moreover, deficits in verbal profiles often coexist with normal or superior performance in the nonverbal domain. Methods To study brain substrates underlying cognitive imbalance in ASD, we capitalized categorical and dimensional IQ profiling as well as multimodal neuroimaging. Results IQ analyses revealed a marked verbal to nonverbal IQ imbalance in ASD across 2 datasets (Dataset-1: 155 ASD, 151 controls; Dataset-2: 270 ASD, 490 controls). Neuroimaging analysis in Dataset-1 revealed a structure-function substrate of cognitive imbalance, characterized by atypical cortical thickening and altered functional integration of language networks alongside sensory and higher cognitive areas. Conclusion Although verbal and nonverbal intelligence have been considered as specifiers unrelated to autism diagnosis, our results indicate that intelligence disparities are accentuated in ASD and reflected by a consistent structure-function substrate affecting multiple brain networks. Our findings motivate the incorporation of cognitive imbalances in future autism research, which may help to parse the phenotypic heterogeneity and inform intervention-oriented subtyping in ASD.

引用

页码：1566 / 1580

页数：15