Kinesin-7 CENP-E in tumorigenesis: Chromosome instability, spindle assembly checkpoint, and applications

被引:2
|
作者
Yang, Yu-Hao [1 ,2 ]
Wei, Ya-Lan [3 ,4 ]
She, Zhen-Yu [1 ,2 ]
机构
[1] Fujian Med Univ, Sch Basic Med Sci, Dept Cell Biol & Genet, Fuzhou, Peoples R China
[2] Fujian Prov Univ, Key Lab Stem Cell Engn & Regenerat Med, Fuzhou, Peoples R China
[3] Fujian Matern & Child Hlth Hosp, Med Res Ctr, Fuzhou, Peoples R China
[4] Fujian Med Univ, Coll Clin Med Obstet & Gynecol & Pediat, Fuzhou, Peoples R China
基金
中国国家自然科学基金;
关键词
kinesin; CENP-E; chromosome instability; cancer; aneuploidy; tumorigenesis; PUTATIVE KINETOCHORE MOTOR; CENTROMERE PROTEIN E; MITOTIC CHECKPOINT; MICROTUBULE ATTACHMENT; ALLOSTERIC INHIBITOR; CANCER-CELLS; E REVEALS; ANEUPLOIDY; MECHANISMS; RESISTANCE;
D O I
10.3389/fmolb.2024.1366113
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Kinesin motors are a large family of molecular motors that walk along microtubules to fulfill many roles in intracellular transport, microtubule organization, and chromosome alignment. Kinesin-7 CENP-E (Centromere protein E) is a chromosome scaffold-associated protein that is located in the corona layer of centromeres, which participates in kinetochore-microtubule attachment, chromosome alignment, and spindle assembly checkpoint. Over the past 3 decades, CENP-E has attracted great interest as a promising new mitotic target for cancer therapy and drug development. In this review, we describe expression patterns of CENP-E in multiple tumors and highlight the functions of CENP-E in cancer cell proliferation. We summarize recent advances in structural domains, roles, and functions of CENP-E in cell division. Notably, we describe the dual functions of CENP-E in inhibiting and promoting tumorigenesis. We summarize the mechanisms by which CENP-E affects tumorigenesis through chromosome instability and spindle assembly checkpoints. Finally, we overview and summarize the CENP-E-specific inhibitors, mechanisms of drug resistances and their applications.
引用
收藏
页数:17
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